Metabolic stress and age drive inflammation and cognitive decline in mice and humans

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-03-20 DOI:10.1002/alz.70060

Sarah E. Elzinga, Kai Guo, Ali Turfah, Rosemary E. Henn, Ian F. Webber-Davis, John M. Hayes, Crystal M. Pacut, Samuel J. Teener, Andrew D. Carter, Diana M. Rigan, Adam M. Allouch, Dae-Gyu Jang, Rachel Parent, Emily Glass, Geoffrey G. Murphy, Stephen I. Lentz, Kevin S. Chen, Lili Zhao, Junguk Hur, Eva L. Feldman

引用次数: 0

Abstract

Metabolic stressors (obesity, metabolic syndrome, prediabetes, and type 2 diabetes [T2D]) increase the risk of cognitive impairment (CI), including Alzheimer's disease (AD). Immune system dysregulation and inflammation, particularly microglial mediated, may underlie this risk, but mechanisms remain unclear.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.