Evaluation of homocysteine, folate, vitamin B12, and vitamin D levels in pregnant women with recurrent vaginitis.

Abstract

Objective: The aim of this study was to evaluate the levels of homocysteine, vitamin B12, folic acid, and vitamin D in pregnant women with recurrent vaginitis and determine whether these parameters contribute to the etiology of the disease.

Methods: The study included 30 pregnant women diagnosed with recurrent vaginitis in their first trimester (group I), who presented at least twice between 1.5.2019 and 1.5.2022 at the obstetrics and gynecology clinic, and 30 healthy pregnant women in their first trimester without any complaints (group II). The vagititis group was compared with the control group for serum levels of vitamin B12, homocysteine, folic acid, and vitamin D.

Results: A comparison of the results between the groups revealed the following: homocysteine levels (μmol/L) were 10.75 (6.38-24.90) in group I (vaginitis positive) and 9.32 (4.26-17.10) in group II (control); vitamin B12 levels (ng/L) were 149.00 (63.00-328.00) in group I and 261.00 (126.00-544.00) in group II; folate levels (μg/L) were 10.56 (3.93-23.33) in group I and 9.48 (3.53-24.10) in group II; vitamin D levels (ng/mL) were 36.54 (23.65-75.68) in group I and 52.45 (26.57-105.00) in group II. Statistically significant elevation in homocysteine levels was observed in the vaginitis group (group I) (p<0.05). Vitamin B12 and D levels were significantly lower in the vaginitis group (group I) (p<0.05).

Conclusion: In pregnant women with recurrent vaginitis, the levels of homocysteine, vitamin B12, and vitamin D may play a role in the etiology of the condition, and vitamins B12 and D may be considered for use in treatment.