Elastosis Amyloidosis as a Histologic Pattern in Cutaneous Amyloidosis.

IF 1.1 4区 医学 Q4 DERMATOLOGY
American Journal of Dermatopathology Pub Date : 2025-06-01 Epub Date: 2025-03-19 DOI:10.1097/DAD.0000000000002952
Eva Sánchez-Martínez, Jörg Schaller
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引用次数: 0

Abstract

Abstract: Elastosis amyloidosis is an exceptionally rare form of cutaneous amyloidosis characterized by amyloid deposition around dermal elastic fibers. To date, only 11 cases have been documented in the literature, some of them with associated systemic involvement. We report a case of a 60-year-old man presenting with an asymptomatic umbilical nodule. Histopathological analysis revealed amyloid deposits in the upper reticular dermis with characteristic distribution around the elastic fibers, confirmed by positive staining with PAS and Congo red. Immunohistochemical staining was positive for cytokeratins but negative for light chains and other systemic amyloid markers, leading to a diagnosis of elastosis amyloidosis with deposit of amyloid-AK, a finding previously unreported. We consider this an incidental discovery that may provide new insights into the etiopathogenesis of amyloidosis in both localized and systemic processes.

弹性淀粉样变是皮肤淀粉样变的一种组织学模式。
摘要:弹性淀粉样变性是一种非常罕见的皮肤淀粉样变性,其特征是淀粉样蛋白在皮肤弹性纤维周围沉积。迄今为止,文献中仅记录了11例,其中一些伴有相关的系统性累及。我们报告一例60岁的男子表现为无症状脐结节。组织病理学分析显示淀粉样蛋白沉积在网状真皮上部,在弹性纤维周围有特征性分布,PAS和刚果红染色阳性证实。免疫组化染色细胞角蛋白呈阳性,但轻链和其他系统性淀粉样蛋白标记呈阴性,诊断为弹性变性淀粉样变性伴淀粉样蛋白ak沉积,这一发现此前未见报道。我们认为这是一个偶然的发现,可能为淀粉样变性在局部和全身过程中的发病机制提供新的见解。
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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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