{"title":"Elastosis Amyloidosis as a Histologic Pattern in Cutaneous Amyloidosis.","authors":"Eva Sánchez-Martínez, Jörg Schaller","doi":"10.1097/DAD.0000000000002952","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Elastosis amyloidosis is an exceptionally rare form of cutaneous amyloidosis characterized by amyloid deposition around dermal elastic fibers. To date, only 11 cases have been documented in the literature, some of them with associated systemic involvement. We report a case of a 60-year-old man presenting with an asymptomatic umbilical nodule. Histopathological analysis revealed amyloid deposits in the upper reticular dermis with characteristic distribution around the elastic fibers, confirmed by positive staining with PAS and Congo red. Immunohistochemical staining was positive for cytokeratins but negative for light chains and other systemic amyloid markers, leading to a diagnosis of elastosis amyloidosis with deposit of amyloid-AK, a finding previously unreported. We consider this an incidental discovery that may provide new insights into the etiopathogenesis of amyloidosis in both localized and systemic processes.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Dermatopathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/DAD.0000000000002952","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract: Elastosis amyloidosis is an exceptionally rare form of cutaneous amyloidosis characterized by amyloid deposition around dermal elastic fibers. To date, only 11 cases have been documented in the literature, some of them with associated systemic involvement. We report a case of a 60-year-old man presenting with an asymptomatic umbilical nodule. Histopathological analysis revealed amyloid deposits in the upper reticular dermis with characteristic distribution around the elastic fibers, confirmed by positive staining with PAS and Congo red. Immunohistochemical staining was positive for cytokeratins but negative for light chains and other systemic amyloid markers, leading to a diagnosis of elastosis amyloidosis with deposit of amyloid-AK, a finding previously unreported. We consider this an incidental discovery that may provide new insights into the etiopathogenesis of amyloidosis in both localized and systemic processes.
期刊介绍：
The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports.
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