The Role and Regulation of Intramuscular Sex Hormones in Skeletal Muscle: A Systematic Review.

IF 5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Viktor Engman, Annabel J Critchlow, Eija K Laakkonen, Mette Hansen, Shaun Mason, Séverine Lamon
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Abstract

Introduction: Serum concentrations of androgens and estrogens, the main male and female sex hormones, respectively, naturally fluctuate across the lifespan. Sex hormones are mainly produced in the gonads, but evidence suggests that they can also be locally synthesized in skeletal muscle. However, little is known about the purpose of intramuscular sex hormones and their role in skeletal muscle. This systematic review aimed to investigate (1) how intramuscular sex hormone concentrations vary across the lifespan, (2) whether exercise affects intramuscular sex hormone concentrations, and (3) whether intramuscular sex hormones are associated with skeletal muscle mass and function.

Methods: Four databases were searched, and studies were included if they contained measurements of intramuscular sex hormones from rodents or healthy males and females free from any hormonal treatment.

Results: Thirteen studies were included. Intramuscular testosterone was reduced in older males compared to their younger counterparts, but comparison of intramuscular sex hormone concentrations between pre- and postmenopausal females yielded inconclusive findings. Chronic exercise decreased androgens and estradiol in females but increased androgens in males. Acute exercise did not change intramuscular hormone concentrations in humans but increased them in rodents. Intramuscular androgens were positively associated with muscle mass and strength in males. In females, conflicting findings were reported for both estradiol and androgens and measures of muscle mass and function.

Conclusion: Current evidence suggests that aging and exercise differentially modulate intramuscular sex hormone concentrations, and their association with muscle mass and function, between males and females and model systems.

骨骼肌肌内性激素的作用和调控:系统综述。
简介:雄激素和雌激素的血清浓度,分别是男性和女性的主要性激素,在整个生命周期中自然波动。性激素主要在性腺中产生,但有证据表明,它们也可以在骨骼肌中局部合成。然而,人们对肌内性激素的作用及其在骨骼肌中的作用知之甚少。本系统综述旨在研究1)肌内性激素浓度在整个生命周期中如何变化,2)运动是否影响肌内性激素浓度,以及3)肌内性激素是否与骨骼肌质量和功能相关。方法:对四个数据库进行检索,如果包含健康雄性和未接受任何激素治疗的雌性或啮齿动物肌肉内性激素的测量,则纳入研究。结果:纳入13项研究。与年轻男性相比,老年男性肌肉内睾酮水平降低,但绝经前和绝经后女性肌肉内性激素浓度的比较没有得出结论性的结果。长期运动降低了女性体内的雄激素和雌二醇,但增加了男性体内的雄激素。剧烈运动不会改变人体肌肉内激素浓度,但会增加啮齿动物的肌肉内激素浓度。肌内雄激素与男性肌肉质量和力量呈正相关。在女性中,雌二醇和雄激素以及肌肉质量和功能的测量结果相互矛盾。结论:目前的证据表明,在男性和女性以及模型系统之间,衰老和运动对肌内性激素浓度及其与肌肉质量和功能的关系有不同的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Endocrinology & Metabolism
Journal of Clinical Endocrinology & Metabolism 医学-内分泌学与代谢
CiteScore
11.40
自引率
5.20%
发文量
673
审稿时长
1 months
期刊介绍: The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
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