Frequency dependence of cortical somatosensory evoked response to peripheral nerve stimulation with controlled afferent excitation.

Disha Gupta, Jodi Brangaccio, Helia Mojtabavi, Jonathan S Carp, Jonathan R Wolpaw, N Jeremy Hill
{"title":"Frequency dependence of cortical somatosensory evoked response to peripheral nerve stimulation with controlled afferent excitation.","authors":"Disha Gupta, Jodi Brangaccio, Helia Mojtabavi, Jonathan S Carp, Jonathan R Wolpaw, N Jeremy Hill","doi":"10.1088/1741-2552/adc204","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective.</i>H-reflex targeted neuroplasticity (HrTNP) protocols comprise a promising rehabilitation approach to improve motor function after brain or spinal injury. In this operant conditioning protocol, concurrent measurement of cortical responses, such as somatosensory evoked potentials (SEPs), would be useful for examining supraspinal involvement and neuroplasticity mechanisms. To date, this potential has not been exploited. However, the stimulation parameters used in the HrTNP protocol deviate from the classically recommended settings for SEP measurements. Most notably, it demands a much longer pulse width, higher stimulation intensity, and lower frequency than traditional SEP settings. In this paper, we report SEP measurements performed within the HrTNP stimulation parameter constraints, specifically characterizing the effect of stimulation frequency.<i>Approach.</i>SEPs were acquired for tibial nerve stimulation at three stimulation frequencies (0.2, 1, and 2 Hz) in 13 subjects while maintaining the afferent volley by controlling the direct soleus muscle response via the Evoked Potential Operant Conditioning System. The amplitude and latency of the short-latency P40 and mid-latency N70 SEP components were measured at the central scalp region using non-invasive electroencephalography.<i>Main</i><i>results.</i>As frequency rose from 0.2 Hz, P40 amplitude and latency did not change. In contrast, N70 amplitude decreased significantly (39% decrease at 1 Hz, and 57% decrease at 2 Hz), presumably due to gating effects. N70 latency was not affected. Across all three frequencies, N70 amplitude increased significantly with stimulation intensity and correlated with M-wave amplitude.<i>Significance</i>. We assess SEPs within an HrTNP protocol, focusing on P40 and N70, elicited with controlled afferent excitation at three stimulation frequencies. HrTNP conditioning protocols show promise for enhancing motor function after brain and spinal injuries. While SEPs offer valuable insights into supraspinal involvement, the stimulation parameters in HrTNP often differ from standard SEP measurement protocols. We address these deviations and provide recommendations for effectively integrating SEP assessments into HrTNP studies.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951476/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neural engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/1741-2552/adc204","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Objective.H-reflex targeted neuroplasticity (HrTNP) protocols comprise a promising rehabilitation approach to improve motor function after brain or spinal injury. In this operant conditioning protocol, concurrent measurement of cortical responses, such as somatosensory evoked potentials (SEPs), would be useful for examining supraspinal involvement and neuroplasticity mechanisms. To date, this potential has not been exploited. However, the stimulation parameters used in the HrTNP protocol deviate from the classically recommended settings for SEP measurements. Most notably, it demands a much longer pulse width, higher stimulation intensity, and lower frequency than traditional SEP settings. In this paper, we report SEP measurements performed within the HrTNP stimulation parameter constraints, specifically characterizing the effect of stimulation frequency.Approach.SEPs were acquired for tibial nerve stimulation at three stimulation frequencies (0.2, 1, and 2 Hz) in 13 subjects while maintaining the afferent volley by controlling the direct soleus muscle response via the Evoked Potential Operant Conditioning System. The amplitude and latency of the short-latency P40 and mid-latency N70 SEP components were measured at the central scalp region using non-invasive electroencephalography.Mainresults.As frequency rose from 0.2 Hz, P40 amplitude and latency did not change. In contrast, N70 amplitude decreased significantly (39% decrease at 1 Hz, and 57% decrease at 2 Hz), presumably due to gating effects. N70 latency was not affected. Across all three frequencies, N70 amplitude increased significantly with stimulation intensity and correlated with M-wave amplitude.Significance. We assess SEPs within an HrTNP protocol, focusing on P40 and N70, elicited with controlled afferent excitation at three stimulation frequencies. HrTNP conditioning protocols show promise for enhancing motor function after brain and spinal injuries. While SEPs offer valuable insights into supraspinal involvement, the stimulation parameters in HrTNP often differ from standard SEP measurement protocols. We address these deviations and provide recommendations for effectively integrating SEP assessments into HrTNP studies.

外周神经受控传入刺激诱发皮层体感觉反应的频率依赖性。
目的:h反射定向神经可塑性(HrTNP)方案是一种很有前途的康复方法,可以改善脑或脊髓损伤后的运动功能。在这种操作性条件反射方案中,同时测量皮层反应,如体感诱发电位(SEPs),将有助于检查棘上受累和神经可塑性机制。迄今为止,这一潜力尚未得到开发。然而,HrTNP方案中使用的增产参数偏离了SEP测量的经典推荐设置。最值得注意的是,与传统的SEP设置相比,它需要更长的脉冲宽度、更高的刺激强度和更低的频率。在本文中,我们报告了在HrTNP刺激参数约束下进行的SEP测量,特别是表征了刺激频率的影响。方法:在13名受试者中,在三种刺激频率(0.2、1和2 Hz)下,通过诱发电位操作条件反射系统控制比目鱼肌的直接反应来维持传入波射,同时获得了SEP。采用无创脑电图测量头皮中央区短潜伏期P40和中潜伏期N70 SEP分量的振幅和潜伏期。结果:当频率从0.2Hz开始升高时,P40振幅和潜伏期没有变化。相比之下,N70振幅明显下降(在1hz时下降39%,在2Hz时下降57%),可能是由于门控效应。N70延迟不受影响。在三个频率下,N70振幅随刺激强度显著增加,且与m波振幅相关。意义:我们在HrTNP方案中评估sep,重点关注P40和N70,在三种刺激频率下控制传入激励。HrTNP调节方案有望增强脑和脊髓损伤后的运动功能。虽然SEP为椎管上受累提供了有价值的见解,但HrTNP的刺激参数通常与标准SEP测量方案不同。我们解决了这些偏差,并提供了将SEP评估有效地整合到HrTNP研究中的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信