Nonadhesive membranes: preparation and characterization of modified PHBHX membranes.

IF 1.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Turkish Journal of Chemistry Pub Date : 2024-11-20 eCollection Date: 2025-01-01 DOI:10.55730/1300-0527.3710
Funda Alkan, Murat Demirbilek, Oktay Aydin, Berrak Gümüşkaya Öcal, Nelisa Laçin Türkoğlu, Mustafa Türk, Mehmet Ali Onur
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引用次数: 0

Abstract

After abdominal surgery, there is a possibility of adhesions between the abdominal organs and the abdominal wall. The adhesions can lead to problems such as chronic pain, intestinal blockage, and infertility. To prevent adhesion, antiadhesion patches can be used. In this study, poly hydroxybutyrate-co-hexanoate membranes were fabricated as antiadhesion patches and modified with either fatty acids or polyethylene glycol. The homogeneity and protein absorption of the membranes were assessed. The effects on blood coagulation factors were determined and the adhesion-proliferation properties of human fibroblast cells on the membranes were determined. The results show that myristic acid slightly increases surface free energy (40.7 ± 4.2 mN/m), decreases polar interaction (6.7 ± 0.7%), and has no effect on cell adhesion or proliferation at low concentrations, but does at high concentrations. Oleic acid slightly increases surface free energy (45.91 ± 4.8 mN/m), does not affect polar interaction (11.4 ± 0.9%), and increases cell proliferation at low concentrations. Both polyethylene glycol 400 and polyethylene glycol 8000 decrease cell adhesion and proliferation and do not change the surface free energy of membranes (39.6 ± 2.6 mN/m and 37.8 ± 1.8 mN/m, respectively), but decrease polar interaction (6.6 ± 0.3% and 5.1 ± 0.2%, respectively). In conclusion, the modified membrane is a good candidate for an antiadhesion patch for abdominal surgery.

非粘附膜:改性PHBHX膜的制备与表征。
腹部手术后,腹部器官与腹壁之间有粘连的可能。这种粘连会导致慢性疼痛、肠梗阻和不孕等问题。为了防止粘连,可以使用防粘连贴片。本研究制备了聚羟基丁酸酯-共己酸酯膜作为抗粘附贴片,并用脂肪酸或聚乙二醇进行改性。对膜的均匀性和蛋白质吸收率进行了评价。测定其对凝血因子的影响,并测定人成纤维细胞对细胞膜的粘附增殖特性。结果表明:肉豆蔻酸在低浓度下能轻微提高细胞表面自由能(40.7±4.2 mN/m),降低极性相互作用(6.7±0.7%),对细胞的粘附和增殖没有影响,但在高浓度下有影响。低浓度油酸能轻微增加表面自由能(45.91±4.8 mN/m),不影响极性相互作用(11.4±0.9%),并促进细胞增殖。聚乙二醇400和聚乙二醇8000均降低了细胞的粘附和增殖,且不改变膜的表面自由能(分别为39.6±2.6 mN/m和37.8±1.8 mN/m),但降低了极性相互作用(分别为6.6±0.3%和5.1±0.2%)。综上所述,该改性膜是腹部手术抗粘连贴片的理想选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Turkish Journal of Chemistry
Turkish Journal of Chemistry 化学-工程:化工
CiteScore
2.40
自引率
7.10%
发文量
87
审稿时长
3 months
期刊介绍: The Turkish Journal of Chemistry is a bimonthly multidisciplinary journal published by the Scientific and Technological Research Council of Turkey (TÜBİTAK). The journal is dedicated to dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, polymeric, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences especially in chemical engineering where molecular aspects are key to the findings. The journal accepts English-language original manuscripts and contribution is open to researchers of all nationalities. The journal publishes refereed original papers, reviews, letters to editor and issues devoted to special fields. All manuscripts are peer-reviewed and electronic processing ensures accurate reproduction of text and data, plus publication times as short as possible.
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