Aydın Sinan Apaydin, Eli Johnson, Prince Antwi, Brett Rocos, Michael M Haglund, Christopher I Shaffrey, Peter Passias, Muhammad M Abd-El-Barr, Khoi Than
{"title":"Synthetic osteobiologics in spine surgery: a review.","authors":"Aydın Sinan Apaydin, Eli Johnson, Prince Antwi, Brett Rocos, Michael M Haglund, Christopher I Shaffrey, Peter Passias, Muhammad M Abd-El-Barr, Khoi Than","doi":"10.55730/1300-0144.5941","DOIUrl":null,"url":null,"abstract":"<p><p>Osteobiologics are increasingly used in orthopedics and spine surgery to facilitate bone healing and prevent nonunion. Synthetic osteobiologics are artificial materials crafted in laboratories that aim to replicate the natural composition and functionality of bone. Notable materials such as calcium phosphate and calcium sulfate are engineered to mirror the mineral aspect of bone. They mimic human bone functionality, exhibiting osteoconductive, osteoinductive, and osteogenic properties. These characteristics promote cell attachment, migration, recruitment, and differentiation. Consequently, synthetic osteobiologics (osteoconductive grafts) have been introduced in bone fracture repair. The main strength of synthetic osteobiologics in spine surgery lies in improving fusion rates and clinical outcomes. The commercial biologics landscape boasts an excess of 350 bone substitute materials, a number that continues to grow exponentially with the development of subtypes. However, the proliferation of these products, primarily driven by the medical device industry and nonacademic entities, has been accompanied by a significant dearth of supporting empirical data. This deficiency underscores the imperative need for rigorous scrutiny and research to establish a solid foundation for their utilization. Healthcare professionals require high-quality research in large prospective studies with satisfactory follow-up periods to interpret and compare the performance of osteobiologics. It is particularly imperative to study the added cost of using these materials in spine surgery. In the current review, we provide an overview of the currently available synthetic osteobiologics used in spine surgery.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"43-51"},"PeriodicalIF":1.2000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913509/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.55730/1300-0144.5941","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Osteobiologics are increasingly used in orthopedics and spine surgery to facilitate bone healing and prevent nonunion. Synthetic osteobiologics are artificial materials crafted in laboratories that aim to replicate the natural composition and functionality of bone. Notable materials such as calcium phosphate and calcium sulfate are engineered to mirror the mineral aspect of bone. They mimic human bone functionality, exhibiting osteoconductive, osteoinductive, and osteogenic properties. These characteristics promote cell attachment, migration, recruitment, and differentiation. Consequently, synthetic osteobiologics (osteoconductive grafts) have been introduced in bone fracture repair. The main strength of synthetic osteobiologics in spine surgery lies in improving fusion rates and clinical outcomes. The commercial biologics landscape boasts an excess of 350 bone substitute materials, a number that continues to grow exponentially with the development of subtypes. However, the proliferation of these products, primarily driven by the medical device industry and nonacademic entities, has been accompanied by a significant dearth of supporting empirical data. This deficiency underscores the imperative need for rigorous scrutiny and research to establish a solid foundation for their utilization. Healthcare professionals require high-quality research in large prospective studies with satisfactory follow-up periods to interpret and compare the performance of osteobiologics. It is particularly imperative to study the added cost of using these materials in spine surgery. In the current review, we provide an overview of the currently available synthetic osteobiologics used in spine surgery.
期刊介绍:
Turkish Journal of Medical sciences is a peer-reviewed comprehensive resource that provides critical up-to-date information on the broad spectrum of general medical sciences. The Journal intended to publish original medical scientific papers regarding the priority based on the prominence, significance, and timeliness of the findings. However since the audience of the Journal is not limited to any subspeciality in a wide variety of medical disciplines, the papers focusing on the technical details of a given medical subspeciality may not be evaluated for publication.