Synthetic osteobiologics in spine surgery: a review.

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Turkish Journal of Medical Sciences Pub Date : 2024-10-25 eCollection Date: 2025-01-01 DOI:10.55730/1300-0144.5941
Aydın Sinan Apaydin, Eli Johnson, Prince Antwi, Brett Rocos, Michael M Haglund, Christopher I Shaffrey, Peter Passias, Muhammad M Abd-El-Barr, Khoi Than
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引用次数: 0

Abstract

Osteobiologics are increasingly used in orthopedics and spine surgery to facilitate bone healing and prevent nonunion. Synthetic osteobiologics are artificial materials crafted in laboratories that aim to replicate the natural composition and functionality of bone. Notable materials such as calcium phosphate and calcium sulfate are engineered to mirror the mineral aspect of bone. They mimic human bone functionality, exhibiting osteoconductive, osteoinductive, and osteogenic properties. These characteristics promote cell attachment, migration, recruitment, and differentiation. Consequently, synthetic osteobiologics (osteoconductive grafts) have been introduced in bone fracture repair. The main strength of synthetic osteobiologics in spine surgery lies in improving fusion rates and clinical outcomes. The commercial biologics landscape boasts an excess of 350 bone substitute materials, a number that continues to grow exponentially with the development of subtypes. However, the proliferation of these products, primarily driven by the medical device industry and nonacademic entities, has been accompanied by a significant dearth of supporting empirical data. This deficiency underscores the imperative need for rigorous scrutiny and research to establish a solid foundation for their utilization. Healthcare professionals require high-quality research in large prospective studies with satisfactory follow-up periods to interpret and compare the performance of osteobiologics. It is particularly imperative to study the added cost of using these materials in spine surgery. In the current review, we provide an overview of the currently available synthetic osteobiologics used in spine surgery.

脊柱手术中的合成骨生物学:综述。
骨生物制剂越来越多地用于骨科和脊柱外科,以促进骨愈合和防止骨不连。合成骨生物学是在实验室中精心制作的人造材料,旨在复制骨的自然成分和功能。值得注意的材料,如磷酸钙和硫酸钙被设计成反映骨骼的矿物方面。它们模仿人类骨骼的功能,表现出骨传导、骨诱导和成骨的特性。这些特征促进细胞附着、迁移、募集和分化。因此,合成骨生物学(骨传导移植物)已被引入骨折修复。合成骨生物学在脊柱外科中的主要优势在于提高融合率和临床效果。商业生物制品领域拥有超过350种骨替代材料,随着亚型的发展,这一数字继续呈指数级增长。然而,这些产品的激增,主要是由医疗器械行业和非学术实体推动的,伴随着支持经验数据的严重缺乏。这一不足突出表明迫切需要进行严格的审查和研究,以便为它们的利用奠定坚实的基础。医疗保健专业人员需要高质量的大型前瞻性研究和令人满意的随访期来解释和比较骨生物学的性能。研究在脊柱手术中使用这些材料的额外成本是非常必要的。在当前的综述中,我们提供了目前可用于脊柱外科的合成骨生物学的概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Turkish Journal of Medical Sciences
Turkish Journal of Medical Sciences 医学-医学:内科
CiteScore
4.60
自引率
4.30%
发文量
143
审稿时长
3-8 weeks
期刊介绍: Turkish Journal of Medical sciences is a peer-reviewed comprehensive resource that provides critical up-to-date information on the broad spectrum of general medical sciences. The Journal intended to publish original medical scientific papers regarding the priority based on the prominence, significance, and timeliness of the findings. However since the audience of the Journal is not limited to any subspeciality in a wide variety of medical disciplines, the papers focusing on the technical  details of a given medical  subspeciality may not be evaluated for publication.
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