Ekin Başak Doğanci, Berna İmge Aydoğan, Nilgün Başkal, Safiye Tuncer
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引用次数: 0
Abstract
Background/aim: The aim of this study was to determine the relationship between clinical and radiological hand osteoarthritis (OA) severity and serum resistin levels in women diagnosed with metabolic syndrome (MetS).
Materials and methods: This research was designed as a case-control study. A total of 87 women, aged 50-65 years, were evaluated between January to March 2014, comprising 29 patients diagnosed with MetS and hand OA (MetS (+), hand OA (+); group 1), 29 patients without MetS but with hand OA (MetS (-), hand OA (+); group 2), and 29 healthy controls (MetS (-), hand OA (-); group 3). The diagnostic criteria of the American College of Rheumatology (ACR) for hand OA and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) for MetS were used. The presence and severity of pain were evaluated according to the Likert scale, function by measuring grip and pinch strength, the presence of disability by Duruöz hand score (DHS), and structural damage by the Osteoarthritis Research Society International (OARSI) atlas classification.
Results: There were no significant differences between the three groups in terms of the presence and severity of pain, functional assessment parameters, disability scores, and serum resistin levels. Structural damage was more severe in group 2. No significant association was found between the serum resistin levels and pain severity, functional assessment parameters, disability scores, hand OA findings (total number of tender joints, the total number of nodules, etc.), and structural damage.
Conclusion: MetS did not contribute to clinical and radiological hand OA severity. Serum resistin levels were not higher in patients with MetS and had no effect on hand OA severity.
背景/目的:本研究旨在确定被诊断患有代谢综合征(MetS)的女性手部骨关节炎(OA)的临床和放射学严重程度与血清抵抗素水平之间的关系:本研究为病例对照研究。2014年1月至3月期间,共对87名年龄在50-65岁之间的女性进行了评估,其中包括29名被诊断患有代谢综合征和手部OA的患者(代谢综合征(+),手部OA(+);第1组)、29名无代谢综合征但患有手部OA的患者(代谢综合征(-),手部OA(+);第2组)和29名健康对照组(代谢综合征(-),手部OA(-);第3组)。手部 OA 采用美国风湿病学会(ACR)的诊断标准,MetS 采用美国国家胆固醇教育计划成人治疗小组 III(NCEP-ATP III)的诊断标准。根据李克特量表评估疼痛的存在和严重程度,通过测量握力和捏力来评估功能,通过杜鲁兹手部评分(DHS)来评估是否存在残疾,并根据国际骨关节炎研究学会(OARSI)图集分类法评估结构性损伤:三组患者在疼痛的存在和严重程度、功能评估参数、残疾评分和血清抵抗素水平方面没有明显差异。血清抵抗素水平与疼痛严重程度、功能评估参数、残疾评分、手部 OA 检查结果(触痛关节总数、结节总数等)和结构损伤之间均无明显关联:结论:MetS并不影响手部OA的临床和放射学严重程度。MetS患者的血清抵抗素水平并不高,对手部OA的严重程度也没有影响。
期刊介绍:
Turkish Journal of Medical sciences is a peer-reviewed comprehensive resource that provides critical up-to-date information on the broad spectrum of general medical sciences. The Journal intended to publish original medical scientific papers regarding the priority based on the prominence, significance, and timeliness of the findings. However since the audience of the Journal is not limited to any subspeciality in a wide variety of medical disciplines, the papers focusing on the technical details of a given medical subspeciality may not be evaluated for publication.