Open-source software to calculate the static sciatic index automatically.

IF 2.4 4区医学 Q4 CELL & TISSUE ENGINEERING

Regenerative medicine Pub Date : 2025-03-18 DOI:10.1080/17460751.2025.2476390

Simão Laranjeira, Owein Guillemot-Legris, Gedion Girmahun, James B Phillips, Rebecca J Shipley

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引用次数: 0

Abstract

Background: The static sciatic index is commonly used in rat models of nerve crush injury to quantify functional recovery from new therapies under evaluation. However, it is challenging to standardize these measurements across different investigations, and the process is labor intensive.

Material/methods: A new machine learning method was previously developed that performs these measurements automatically and consistently. Here, the approach is tested using two data sets that use different experimental setups, and end-user requirements are evaluated.

Results: The model's outputs presented a nerve regeneration profile comparable to the manual measurements and outperformed the latter by having a much tighter standard deviation (± 5- ± 10 compared to ± 10 - ± 50).

Conclusion: An inexpensive automatic tool that can perform functional analysis for nerve repair research was developed and tested. The software is available open source to facilitate its dissemination and use in quantifying recovery from peripheral nerve crush injury.

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来源期刊

Regenerative medicine 医学-工程：生物医学

CiteScore

4.20

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.