Amniocentesis and Risk of Fetal Loss in Dichorionic-Diamniotic Twin Pregnancy: A Case-Control Study.

IF 2.7 2区医学 Q2 GENETICS & HEREDITY

Prenatal Diagnosis Pub Date : 2025-03-18 DOI:10.1002/pd.6777

Sofia Roero, Agata Ingala, Silvana Arduino, Carlotta Bossotti, Simona Bastonero, Francesca Maria Comoglio, Ilaria Dusini, Annasilvia Pertusio, Roberto Scali, Simona Sdei, Alberto Revelli, Andrea Sciarrone

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引用次数: 0

Abstract

Objective: There is a paucity of data regarding the risk of fetal loss due to invasive prenatal diagnosis in twins. The aim of the present study is to assess the rate of amniocentesis-related fetal loss in uncomplicated dichorionic-diamniotic (DCDA) twin pregnancies.

Methods: Retrospective observational case-control study. DCDA twin pregnancies undergoing amniocentesis between January 2010 and December 2023 formed the case group. The control group comprised counterparts who did not undergo amniocentesis. The primary outcome of the study was procedure-related fetal loss. Secondary outcomes were miscarriage rate, overall fetal loss and gestational age at birth.

Results: Our dataset included 220 and 662 women in the case and control groups, respectively. No difference in the primary outcome was found: procedure-related fetal loss of one fetus was 0.9% in the case group and 1.1% in the control group, and of both fetuses it was 0.5% in both groups (p = 0.982). No difference was found in secondary outcomes: the fetal loss rate of one fetus was 1.8% in the case group and 2.1% in the control group, while that of both fetuses it was 0.5% and 0.8% respectively (p = 0.853). Multivariate analysis confirmed the nonsignificant effect of amniocentesis on the risk of fetal loss.

Conclusion: Amniocentesis does not seem to increase the risk of fetal loss in uncomplicated DCDA twin pregnancies above the baseline risk of loss among twin gestations.

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羊膜穿刺术与双羊膜双羊膜双胎妊娠胎儿丢失的风险：一项病例-对照研究。

目的：关于双胞胎有创产前诊断导致胎儿丢失风险的数据缺乏。本研究的目的是评估无并发症双绒毛膜双羊膜双胎（DCDA）双胎妊娠中羊膜穿刺术相关胎儿丢失的发生率。方法：回顾性观察性病例-对照研究。该病例组为2010年1月至2023年12月间行羊膜穿刺术的DCDA双胎妊娠。对照组由未进行羊膜穿刺术的对照组组成。该研究的主要结果是手术相关的胎儿丢失。次要结局是流产率、胎儿总损失和出生时胎龄。结果：我们的数据集分别包括病例组和对照组的220名和662名女性。在主要结局中没有发现差异：病例组与手术相关的一个胎儿损失为0.9%，对照组为1.1%，两组中两个胎儿的损失为0.5% （p = 0.982）。两组继发性结局无差异，病例组1胎损失率为1.8%，对照组为2.1%，两胎损失率分别为0.5%和0.8% （p = 0.853）。多因素分析证实羊膜穿刺术对胎儿流产风险无显著影响。结论：羊膜穿刺术似乎不会增加无并发症DCDA双胎妊娠的胎儿丢失风险，高于双胎妊娠丢失的基线风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prenatal Diagnosis 医学-妇产科学

CiteScore

5.80

自引率

13.30%

发文量

204

审稿时长

2 months

期刊介绍： Prenatal Diagnosis welcomes submissions in all aspects of prenatal diagnosis with a particular focus on areas in which molecular biology and genetics interface with prenatal care and therapy, encompassing: all aspects of fetal imaging, including sonography and magnetic resonance imaging; prenatal cytogenetics, including molecular studies and array CGH; prenatal screening studies; fetal cells and cell-free nucleic acids in maternal blood and other fluids; preimplantation genetic diagnosis (PGD); prenatal diagnosis of single gene disorders, including metabolic disorders; fetal therapy; fetal and placental development and pathology; development and evaluation of laboratory services for prenatal diagnosis; psychosocial, legal, ethical and economic aspects of prenatal diagnosis; prenatal genetic counseling