Pueraria Radix and Its Major Constituents Against Metabolic Diseases: Pharmacological Mechanisms and Potential Applications.

IF 6.3 2区医学 Q1 CHEMISTRY, MEDICINAL

Phytotherapy Research Pub Date : 2025-03-18 DOI:10.1002/ptr.8464

Yicheng Lei, Ruiyuan Zhang, Yan Li, Huiwen Pang, Qiang Fu, Chen Chen, Fang Liu

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引用次数: 0

Abstract

Metabolic diseases (MD), a series of chronic disorders, severely decrease the quality of life for patients but also cause a heavy economic burden. The ancient Chinese herb Pueraria Radix (PR) plays an important role in curing MD. Up to now, the bioactive compounds found in PR demonstrate effective actions in treating various metabolic disorders. This paper systematically summarizes the recent research advances on the pharmacological activities of PR and its constituents, explains the underlying mechanisms of preventing and treating MD. Besides, phytochemicals, drug delivery systems, clinical application, and safety of PR have been researched, hoping to provide valuable information for the future application, development, and improvement of PR as well as MD treatment. The information about PR was collected from various sources including classic books about Chinese herbal medicine and scientific databases including Web of Science, PubMed, ScienceDirect, Springer, ACS, SCOPUS, CNKI, Google Scholar, X-MOL, and WANFANG using keywords given and terms like pharmacological and phytochemical details of this plant. The chemical constituents isolated and identified from PR, such as isoflavones including puerarin, formononetin, daidzin, daidzein, genistein, and so forth, polysaccharides, alkaloids, starch, and other components have been proved to have the effect of anti-diabetic, anti-obesity, anti-atherosclerotic, anti-osteoporotic, anti-hypertensive, anti-hyperlipidemia, and anti-nonalcoholic fatty liver disease (NAFLD) through PI3K/Akt, Nrf2/HO-1, LOX-1/ROS/Akt/eNOS, ERK1/2-Nrf2, GLP-1R, Caspase, MAPK, NF-κB, and other anti-inflammatory and anti-oxidant signaling pathways. Also, the active contents of PR have been designed as drug delivery systems to improve the therapeutic effects of MD. It provides a preclinical basis for the efficacy of PR as an effective therapeutic agent for the prevention and treatment of MD. Even so, further studies are still needed to enhance bioavailability and expand clinical application.

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葛根及其主要成分抗代谢性疾病：药理机制及潜在应用。

代谢性疾病（MD）是一系列慢性疾病，严重降低了患者的生活质量，也造成了沉重的经济负担。古中草药葛根（Pueraria Radix， PR）在MD的治疗中发挥着重要作用。迄今为止，葛根中发现的生物活性化合物对治疗多种代谢紊乱具有有效作用。本文系统地综述了近年来有关白藜芦醇及其成分药理作用的研究进展，阐述了白藜芦醇预防和治疗MD的机制，并对其植物化学成分、给药系统、临床应用、安全性等方面进行了研究，以期为今后白藜芦醇的应用、开发和改进以及治疗MD提供有价值的信息。PR的相关信息收集自各种来源，包括中草药经典书籍和科学数据库，包括Web of Science、PubMed、ScienceDirect、施普林格、ACS、SCOPUS、CNKI、谷歌Scholar、X-MOL和万方，使用给出的关键词和术语，如该植物的药理和植物化学细节。从PR中分离鉴定出的化学成分，如葛根素、苦参花素、大豆苷元、大豆苷元、金木黄酮等异黄酮、多糖、生物碱、淀粉等成分，通过PI3K/Akt、Nrf2/HO-1、LOX-1/ROS/Akt/eNOS、ERK1/2-Nrf2、GLP-1R、Caspase、MAPK，证明其具有抗糖尿病、抗肥胖、抗动脉粥样硬化、抗骨质疏松、抗高血压、抗高脂血症、抗非酒精性脂肪性肝病（NAFLD）的作用。NF-κB，以及其他抗炎和抗氧化信号通路。PR的活性成分已被设计为药物传递系统，以提高MD的治疗效果，为PR作为预防和治疗MD的有效药物提供了临床前基础，但仍需进一步研究以提高生物利用度，扩大临床应用。

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来源期刊

Phytotherapy Research 医学-药学

CiteScore

12.80

自引率

5.60%

发文量

325

审稿时长

2.6 months

期刊介绍： Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.