Therapeutic Potential of Phytochemicals as Adjuvants in Head and Neck Cancer.

Abstract

Owing to the developments in various therapeutic modalities, cancer treatment has come a long way, including the discovery of various anticancer drugs, innovations in delivery technology, and increased personalization of treatments. Despite this, head and neck cancer (HNC) is a cancer that has eluded the current conventional treatments. To improve quality of life and preserve vital organ function in patients with HNC, there is a need for research into therapeutic regimes that would reduce the toxicity of the current therapeutic modalities. The use of a single approach has not been enough to completely eradicate this malignancy. Therefore, the use of adjuvants and combinatorial approaches, using molecules from natural compounds that have no or minimal side effects, is a growing area of research. One objective of this review was to clarify the potentiality of novel therapeutic strategies for HNC, such as the use of phytochemicals as adjuvants with chemotherapy or radiotherapy, and use of nano-formulation for therapeutic delivery. Another objective of this review was to delineate the associated challenges in the clinical application of these therapies in HNC. Possible strategies for overcoming critical issues associated with the clinical application of phytochemicals for HNC are also discussed.