Airway Anomalies Predict Risk of Pediatric Pulmonary Hypertension.

IF 2.7 3区 医学 Q1 PEDIATRICS
Elana R Kriegel, Aditya Srinivasan, Luke Mammen, Harini Venkataganesh, Jess T Randall, Lara Reichert
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引用次数: 0

Abstract

Introduction: Pediatric pulmonary hypertension (PH) significantly contributes to morbidity and mortality due to the progressive nature of the disease in some subtypes, which leads to severe right heart failure, impaired oxygenation, and subsequent complications of chronic hypoxia, and side effects of long-term therapies. Associations between PH and airway anomalies in pediatric patients are complex and multifactorial. Better understanding of these associations will help identify which patients should receive screening for PH by multidisciplinary care teams (pediatric otolaryngology, cardiology, pulmonology).

Methods: A retrospective, observational, single institution, cross-sectional study was performed using inpatient and emergency department visit records and operating room reports from January 2021 to January 2023 of pediatric patients. Odds ratios and logistic regression were used to determine the association between PH and other cardiopulmonary anomalies.

Results: PH was associated with cardiac and airway anomalies (Odds ratio, 95% CI; 3.26, 1.01-10.5, p < 0.05; Logistic Regression, pseudo-R2 = 0.440, p < 0.01), especially bronchopulmonary dysplasia (BPD), atrial septal defect (ASD), ventricular septal defect (VSD), patent ductus arteriosus (PDA), chronic lung disease/respiratory failure (CLD), and Down Syndrome (DS).

Conclusion: Our findings demonstrate PH is highly co-morbid with other cardiopulmonary anomalies and provide an estimate of the risk of having a concurrent congenital disease and PH. Patients with multiple comorbidities are at high risk for developing PH and should receive screening for PH via coordinated care by multidisciplinary care teams. Our results, with further quantification at other sites, could help further development of PH screening guidelines.

气道异常预测小儿肺动脉高压的风险。
导读:儿童肺动脉高压(PH)在某些亚型中具有进行性,可导致严重的右心衰、氧合受损和随后的慢性缺氧并发症,以及长期治疗的副作用,从而显著提高发病率和死亡率。儿科患者PH值与气道异常之间的关系是复杂和多因素的。更好地了解这些关联将有助于确定哪些患者应该接受多学科护理团队(儿科耳鼻喉科、心脏科、肺科)的PH筛查。方法:对2021年1月至2023年1月儿科患者的住院、急诊就诊记录和手术室报告进行回顾性、观察性、单机构、横断面研究。比值比和逻辑回归用于确定PH与其他心肺异常之间的关系。结果:PH与心脏和气道异常相关(优势比,95% CI;结论:我们的研究结果表明,PH与其他心肺异常高度合并症,并提供了并发先天性疾病和PH的风险估计。患有多种合并症的患者发生PH的风险很高,应通过多学科护理团队的协调护理接受PH筛查。我们的结果,以及在其他位点的进一步量化,可能有助于进一步制定PH筛选指南。
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来源期刊
Pediatric Pulmonology
Pediatric Pulmonology 医学-呼吸系统
CiteScore
6.00
自引率
12.90%
发文量
468
审稿时长
3-8 weeks
期刊介绍: Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.
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