T2-weighted MRI radiomics for the prediction of pediatric and young adult rhabdomyosarcoma alveolar subtype and distant metastasis: a pilot study.

Abstract

Introduction: Rhabdomyosarcomas are the most common soft tissue sarcoma in children. While treatment outcomes have improved, risk-based therapy classification relies on staging and tumor subtypes for therapeutic planning.

Objective: This study investigated the utility of T2-weighted MR radiomics features and machine learning models in identifying the presence of distant metastasis and alveolar histological subtypes at baseline imaging in children diagnosed with rhabdomyosarcoma.

Materials and methods: This retrospective cross-sectional study utilized MRIs from 86 patients, 49 (median age (IQR) 59 months (37-161), alveolar subtype=15, distant metastasis=9) of whom had been imaged at outside imaging centers (training set); and 37 (median age 52 months (24-164), alveolar subtype=14, distant metastasis=8) of whom were imaged at our institution (holdout validation set). Radiomic features were extracted from T2-weighted images. We selected features that demonstrated intra-scan repeatability and used maximum relevance and minimum redundancy supervised feature selection to identify the 50 most important features. Lasso logistic regression and support vector machine (SVM) classifiers were trained to predict binary outcomes. The median of all predictions for a given patient was used as patient-level predictions. DeLong's test compared the area under the receiver operating characteristic curves (AUC). Cut-offs obtained by maximizing the Youden index were evaluated on an external validation set, and accuracy metrics were reported.

Results: On the validation set, the Lasso and SVM classifiers obtained patient level AUCs of 0.76 (95% CI 0.59-0.94) and 0.73 (0.54-0.92), respectively, in predicting alveolar subtype, with the Lasso regressor obtaining 71.4% (41.9-91.6) sensitivity and 60.9% (38.5-80.3) specificity. When predicting the presence of distant metastasis, the Lasso and SVM classifier had AUCs of 0.81 (0.67-0.95) and 0.77 (0.58-0.97), respectively. There were no differences between model performance (P>0.05). A total of 12 and 18 features had nonzero coefficients in the Lasso regressors for predicting alveolar subtype and tumor metastasis, respectively.

Conclusion: MRI radiomics from baseline T2-weighted MRI demonstrated potential in predicting alveolar subtype and distant metastatic disease at presentation. Larger studies are needed to explore multinomial multiclass models for better prognostication of pediatric rhabdomyosarcomas.