Influence of insulin sensitivity on food cue evoked functional brain connectivity in children

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-03-16 DOI:10.1016/j.neuroimage.2025.121154

Lorenzo Semeia , Ralf Veit , Sixiu Zhao , Shan Luo , Brendan Angelo , Andreas L. Birkenfeld , Hubert Preissl , Anny H. Xiang , Stephanie Kullmann , Kathleen A. Page

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引用次数: 0

Abstract

Objective

Insulin resistance during childhood is a risk factor for developing type 2 diabetes and other health problems later in life. Studies in adults have shown that insulin resistance affects regional and network activity in the brain which are vital for behavior, including ingestion and metabolic control. To date, no study has investigated how brain connections during exposure to food cues are association with peripheral insulin sensitivity in children.

Methods

We included 53 children (36 girls) between the age of 7–11 years, who underwent an oral Glucose Tolerance Test (oGTT) to estimate peripheral insulin sensitivity (ISI). Brain responses were measured using functional magnetic resonance imaging (fMRI) before and after glucose ingestion. We compared food-cue task-based activity and functional connectivity (FC) between children with lower and higher ISI, adjusted for age and BMIz.

Results

Independent of prandial state (i.e., glucose ingestion), children with lower ISI showed higher FC between the anterior insula and caudate and lower FC between the posterior insula and mid temporal cortex than children with higher ISI. Sex differences were found based on prandial state and peripheral insulin sensitivity in the insular FC. No differences were found on mean brain responses to food cues.

Conclusions

In response to food cues, children with lower peripheral insulin sensitivity exhibited distinctive patterns of neural connectivity, notably in the insula's functional connections, when contrasted with their counterparts with higher peripheral insulin sensitivity. These differences might influence eating behavior and future risk of developing diabetes.

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胰岛素敏感性对儿童食物线索诱发的功能性脑连通性的影响。

目的：儿童时期的胰岛素抵抗是日后患2型糖尿病和其他健康问题的危险因素。对成人的研究表明，胰岛素抵抗会影响大脑中对行为至关重要的区域和网络活动，包括摄入和代谢控制。迄今为止，还没有研究调查儿童接触食物线索时大脑连接与外周胰岛素敏感性之间的关系。方法：我们纳入了53名7-11岁的儿童（36名女孩），他们接受了口服葡萄糖耐量试验（oGTT）来评估外周胰岛素敏感性（ISI）。使用功能性磁共振成像（fMRI）测量摄入葡萄糖前后的脑反应。我们比较了低ISI和高ISI儿童的食物线索任务型活动和功能连通性（FC），并根据年龄和bmi进行了调整。结果：与进食状态（即葡萄糖摄入）无关，ISI较低的儿童比ISI较高的儿童表现出较高的前岛和尾状核之间的FC，以及较低的后岛和中颞叶皮层之间的FC。性别差异是基于进食状态和外周胰岛素敏感性。大脑对食物线索的平均反应没有发现差异。结论：与外周胰岛素敏感性较高的儿童相比，外周胰岛素敏感性较低的儿童对食物线索的反应表现出独特的神经连接模式，特别是在脑岛的功能连接方面。这些差异可能会影响饮食行为和未来患糖尿病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.