Pregnancy and birth outcomes in women with multiple sclerosis: Comparison of the RESPONSE study to the general French population.

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2025-03-01 Epub Date: 2025-03-18 DOI:10.1177/13524585251316474

Elisabeth Maillart, Fabien Rollot, Emmanuelle Leray, Lakhdar Benyahya, Bertrand Bourre, Clarisse Carra-Dallière, Romain Casey, Kumaran Deiva, Catherine Girod, Anne-Marie Guennoc, Romain Marignier, Pierre Labauge, Caroline Bensa, Jérôme De Sèze, Eric Berger, Damien Biotti, Saskia Bresch, Eric Thouvenot, Thibault Moreau, Nathalie Derache, Hélène Zéphir, Emmanuelle Le Page, Pierre Clavelou, Olivier Casez, David Laplaud, Arnaud Kwiatkowski, Clara Grosset-Janin, Sophie Pittion-Vouyovitch, Aurélie Ruet, Amélie Dos Santos, Florence Robert-Varvat, Nathalie Morel, Christine Lebrun-Frenay, Sandra Vukusic

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引用次数: 0

Abstract

Background: Retrospective studies did not show strong evidence of higher risk of adverse neonatal or pregnancy outcomes in women with multiple sclerosis (MS) compared to general population, but there are contradictory data on prematurity, cesarean section, and small birthweight for gestational age (SGA).

Methods: We compared pregnancy and birth outcomes in MS women included in RESPONSE, a French prospective cohort, with a recent survey (Enquête Nationale Périnatale (ENP)) describing leading indicators in perinatal epidemiology in France.

Results: On 7 April 2023, 476 pregnancies (461 MS women, 482 expected newborns) from RESPONSE were available. The ENP study reported 12,723 women and 12,939 expected newborns in March 2021. MS patients were older (mean age 32.6 ± 4.4 vs. 30.9 ± 5.3 years, p < 0.001), with similar rate of cesarean (23.8% vs. 21.4%, p = 0.115) and use of locoregional analgesia (86.6% vs. 85.1%, p = 0.51). Preterm birth was less frequent (4.0% vs. 7.0%, p = 0.001). Birthweight of children from MS mothers was similar to general population (3240 ± 477.2 vs. 3264.5 ± 552.9 g, p = 0.22), with slightly more children with SGA (13.4% vs. 9.8%, p = 0.04).

Conclusion: This prospective and contemporary comparison of pregnancy in MS women and the French population provides reassuring results. In the future, we need to assess the impact of disease-modifying treatment exposure during conception.

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多发性硬化症妇女的妊娠和分娩结局：RESPONSE研究与法国普通人群的比较

背景：回顾性研究没有显示强有力的证据表明多发性硬化症（MS）妇女与一般人群相比有更高的不良新生儿或妊娠结局风险，但在早产、剖宫产和胎龄小出生体重（SGA）方面存在矛盾的数据。方法：我们将法国前瞻性队列RESPONSE中纳入的MS妇女的妊娠和分娩结果与最近法国围产期流行病学主要指标调查（Enquête Nationale pembroina atale (ENP)）进行了比较。结果：截至2023年4月7日，RESPONSE共有476例妊娠（461例MS， 482例待产新生儿）。ENP的研究报告称，2021年3月，12,723名女性和12,939名新生儿即将出生。MS患者年龄较大（平均年龄32.6±4.4岁比30.9±5.3岁，p = 0.115），使用局部镇痛（86.6%比85.1%,p = 0.51）。早产发生率较低（4.0%比7.0%,p = 0.001）。MS母亲的孩子出生体重与一般人群相似（3240±477.2 g vs. 3264.5±552.9 g, p = 0.22）， SGA的孩子略多（13.4% vs. 9.8%, p = 0.04）。结论：这一前瞻性和当代妊娠MS妇女和法国人口的比较提供了令人放心的结果。在未来，我们需要评估在受孕期间接受治疗对疾病的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585