Circuit-specific neural perturbations and recovery in methamphetamine addiction in a mouse model

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2025-03-16 DOI:10.1016/j.neulet.2025.138201

Pongpanot Wongveerakul , Dania Cheaha , Ekkasit Kumarnsit , Nifareeda Samerphob

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Abstract

Drug addiction is characterized by profound brain adaptations, including altered neural circuit dynamics in reward-related regions, which reinforce compulsive drug-seeking behavior. This study investigated the effects of 5 mg/kg methamphetamine (METH) administration on brain activity measured by local field potentials (LFPs) in the nucleus accumbens (NAc) and dorsal hippocampus (dHP) of C57BL/6 mice. The study further examined the sensitivity of these brain regions during an abstinent period on day 8 and following a low-dose METH challenge. METH administration reduced theta power activity and enhanced gamma activity in the NAc, but decreased alpha2 power with specific high gamma increases in the dHP during conditioning and challenge phases. The sleep analysis revealed a reduction in NREM during the conditioning and challenge phases, however, these parameters returned to normal after 8 days abstinence from METH. These findings suggest that repeated METH administration induces neural sensitization and alters sleep architecture. However, the minimization of adverse neural changes, particularly in sleep regulation, highlights potential avenues for therapeutic applications in managing addiction and promoting recovery.

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小鼠模型中甲基苯丙胺成瘾的电路特异性神经扰动和恢复。

药物成瘾的特点是深刻的大脑适应，包括改变奖赏相关区域的神经回路动力学，这加强了强迫性的药物寻求行为。研究了5 mg/kg冰毒（METH）对C57BL/6小鼠伏隔核（NAc）和海马背侧（dHP）脑活动的影响。该研究进一步检查了在第8天的戒断期和低剂量冰毒刺激后这些大脑区域的敏感性。甲基安非他明降低了NAc的θ波能量活动，增强了γ波活动，但降低了dHP的α 2能量，并在调节和刺激阶段增加了特定的高γ波。睡眠分析显示，在条件反射和挑战阶段，NREM减少，然而，这些参数在戒掉冰毒8 天后恢复正常。这些发现表明，反复服用甲基苯丙胺可诱导神经敏化并改变睡眠结构。然而，最小化不利的神经变化，特别是在睡眠调节方面，突出了在管理成瘾和促进康复方面的治疗应用的潜在途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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