Gita Erta, Gita Gersone, Antra Jurka, Peteris Tretjakovs
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引用次数: 0
Abstract
Background: Salivary amylase activity (SAA) is recognized as a potential biomarker for metabolic health. Previous studies suggest an association between SAA and insulin sensitivity, but the mechanisms remain unclear. This study investigates the relationship between SAA, visceral fat (VF), and the triglyceride-glucose (TyG) index to clarify the pathways linking SAA to metabolic risk factors.
Methods: This cross-sectional study analysed data from women of reproductive age who were classified as overweight. Linear regression models were used to assess associations between salivary amylase activity (SAA), visceral fat (VF) and the triglyceride-glucose (TyG) index, while adjusting for confounding variables such as age, body mass index (BMI), physical activity and dietary patterns. Mediation analysis was conducted to determine whether VF mediates the relationship between SAA and the TyG index.
Results: Higher SAA was inversely associated with VF (β = -0.45, 95% CI: -0.65 to -0.25, p < 0.001). No direct association was observed between SAA and TyG index (β = -0.10, 95% CI: -0.25 to 0.05, p = 0.18) after adjustment for covariates. Mediation analysis revealed that visceral fat significantly mediated the relationship between SAA and the TyG index. The indirect effect of SAA on the TyG index through VF (A × B) was statistically significant (β = -0.16, 95% CI: -0.26 to -0.08), accounting for 45% of the total effect.
Conclusions: These findings suggest that higher SAA may confer metabolic benefits by reducing VF, thereby indirectly influencing the TyG index. This highlights the critical role of VF in mediating the protective effects of SAA on metabolic health and provides insights into potential pathways for intervention.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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