Markers of Inflammation and Bone Turnover in Type 2 Diabetic Patients at Risk of Charcot Arthropathy.

IF 0.5 4区医学 Q4 ORTHOPEDICS

Journal of the American Podiatric Medical Association Pub Date : 2025-03-13 DOI:10.7547/24-116

Salini Dharmadas, Harish Kumar, Minnie Pillay, Thacho Sukumaran Mangalanandan, Lakshmanan Vivek, Valiyaparambil Pavithran Praveen, Arun Bal

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引用次数: 0

Abstract

Background: Recent research indicates that inflammation-induced changes in the RANKL/RANK/OPG pathway play a significant role in the development of Charcot arthropathy. Considering the severe implications of Charcot arthropathy, cost-effective screening of patients at risk of the disease could prove to be an effective preventative strategy. As an initial endeavour in our attempt to identify a predictive biomarker for Charcot arthropathy, we conducted an analysis of inflammation and bone turnover markers in diabetic patients at risk of Charcot arthropathy. We then compared these markers with those of patients in the acute stage of Charcot arthropathy and healthy controls.

Methods: In this cross-sectional study, 45 subjects were carefully selected and categorized into three groups, with 15 individuals in each group. Group 1 encompassed patients over 50 years of age, with more than 10 years of type 2 diabetes and severe neuropathy (DN). Group 2 consisted of patients diagnosed with acute-stage Charcot arthropathy (aCA), while Group 3 consisted of healthy, non-diabetic, age-matched controls (N). Serum inflammatory markers and bone turnover markers were analyzed across these groups.

Results: Significant differences were only noted in the median values of HbA1c (P=0.000), VPT (P=0.000), and OPG (P=0.009) among the groups under study. No notable increase was observed in the serum levels of the inflammatory marker IL6 (P value - 0.071), the bone resorption marker TRAP5B (P value - 0.066), or the bone formation marker BALP (0.251) across the groups. However, a positive correlation was identified between IL-6 and OPG in the aCA group (r=0.900, P=0.001).

Conclusion: In alignment with the existing literature, serum OPG levels were found to be elevated in the aCA group compared to the control groups. The observed similarities in serum levels of IL6 and TRAP5B across the groups are noteworthy and warrant further investigation.

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有患夏科氏关节病风险的 2 型糖尿病患者的炎症和骨质流失标志物

背景：近期研究表明，炎症诱导的RANKL/RANK/OPG通路改变在Charcot关节病的发生发展中起重要作用。考虑到Charcot关节病的严重影响，对有该疾病风险的患者进行具有成本效益的筛查可能是一种有效的预防策略。作为我们确定Charcot关节病预测生物标志物的初步尝试，我们对有Charcot关节病风险的糖尿病患者的炎症和骨转换标志物进行了分析。然后，我们将这些标志物与沙科关节病急性期患者和健康对照进行比较。方法：在横断面研究中，精心挑选45名受试者，将其分为3组，每组15人。第一组患者年龄超过50岁，患有2型糖尿病和严重神经病变（DN）超过10年。第2组由诊断为急性期Charcot关节病（aCA）的患者组成，而第3组由健康、非糖尿病、年龄匹配的对照组(N)组成。分析两组患者的血清炎症标志物和骨转换标志物。结果：两组间仅HbA1c （P=0.000）、VPT （P=0.000）、OPG （P=0.009）的中位数存在显著差异。各组血清炎症标志物IL6 （P值- 0.071）、骨吸收标志物TRAP5B （P值- 0.066）和骨形成标志物BALP（0.251）水平均无显著升高。然而，aCA组IL-6与OPG呈正相关（r=0.900， P=0.001）。结论：与现有文献一致，与对照组相比，aCA组血清OPG水平升高。各组血清il - 6和TRAP5B水平的相似性值得注意，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Podiatric Medical Association 医学-整形外科

CiteScore

1.10

自引率

0.00%

发文量

128

审稿时长

6-12 weeks

期刊介绍： The Journal of the American Podiatric Medical Association, the official journal of the Association, is the oldest and most frequently cited peer-reviewed journal in the profession of foot and ankle medicine. Founded in 1907 and appearing 6 times per year, it publishes research studies, case reports, literature reviews, special communications, clinical correspondence, letters to the editor, book reviews, and various other types of submissions. The Journal is included in major indexing and abstracting services for biomedical literature.