Navigating transfusion challenges: Bombay blood group in focus.

IF 1.4 Q3 EDUCATION, SCIENTIFIC DISCIPLINES
Journal of Education and Health Promotion Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI:10.4103/jehp.jehp_519_24
Romesh Jain, Vilasini Patil, Pratul Sinha, Snehashish Mishra, Rut Naik
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Abstract

"Bombay" and "Para-Bombay" phenotypes are uncommon blood groups with absence or deficiency of H antigen. These individuals possess anti-H antibodies and crossmatching with ABO blood group packed red blood cells (PRBC) becomes incompatible. In this report, we find out alternative strategy (patient blood management) for the management of anemia in Bombay blood group patient. Case: A 49-year-old woman referred to our hospital with severe anemia (Hb = 6 gm/dl). On history patient visited to peripheral hospital with complains of fatigue and weakness. Patient was transfused one unit of group O PRBC and suffered hemolytic transfusion reaction. At our center, blood group analysis was performed by the standard tube technique. In the forward group, there was negative reaction with anti-A, anti-B, and anti-AB sera, and 4+ reaction was showing with anti-D sera. In reverse grouping, there was 4 + reaction with A cell, B cell, and O cell and negative reaction with autocontrol. This suggests that patient was having a strong antibody other than anti-A and anti-B, which was reacting strongly with O cell at all temperatures. Anti-H lectin reaction was negative. The patient was diagnosed with probable Bombay phenotype (hh), and we tried to manage anemia with patient blood management. Patient was started on oral iron supplementation, and after 2 month of treatment, the patient had Hb of 13.3 gm/dl with no complains of fatigue and weakness. In this report, we reiterate the importance of patient blood management and would also like to emphasize to implement the rare group registry in India.

应对输血挑战:聚焦孟买血型。
“孟买”型和“类孟买”型是罕见的血型,缺乏或缺乏H抗原。这些个体具有抗h抗体,与ABO血型填充红细胞(PRBC)交叉配型变得不相容。在本报告中,我们发现了孟买血型患者贫血管理的替代策略(患者血液管理)。病例:一名49岁女性因严重贫血(Hb = 6 gm/dl)转诊至我院。病史患者到周边医院就诊,主诉疲乏无力。患者输注1单位O组PRBC,出现溶血性输血反应。在本中心,采用标准管技术进行血型分析。正向组抗a、抗b、抗ab血清呈阴性反应,抗d血清呈4+反应。反向组A细胞、B细胞、O细胞4 +反应,自动控制阴性反应。这说明患者体内除抗a和抗b抗体外,还有一种较强的抗体,在任何温度下都能与O细胞发生强烈反应。抗h凝集素反应阴性。患者被诊断为可能的孟买表型(hh),我们试图通过患者血液管理来管理贫血。患者开始口服补铁,治疗2个月后,患者Hb为13.3 gm/dl,无疲劳和虚弱症状。在本报告中,我们重申患者血液管理的重要性,并强调在印度实施罕见组登记。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.60
自引率
21.40%
发文量
218
审稿时长
34 weeks
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