Surgical Treatment of Synchronous Liver-only Oligometastatic Pancreatic Adenocarcinoma: a Systematic Review and Meta-analysis of Long-term Outcomes.

IF 12.5 2区 医学 Q1 SURGERY
Claudio Fiorillo, Lodovica Langellotti, Edoardo Panza, Giuseppe Daloiso, Beatrice Biffoni, Chiara Lucinato, Maria Carmen Puzzangara, Giuseppe Massimiani, Teresa Mezza, Davide De Sio, Roberta Menghi, Vincenzo Tondolo, Sergio Alfieri, Giuseppe Quero
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引用次数: 0

Abstract

Background: The potential long-term survival benefits of surgical resection for synchronous liver-only metastases of pancreatic ductal adenocarcinoma (liver oligo-PDAC) remain controversial. This systematic review and meta-analysis aim to compare the current evidence on long-term survival outcomes between surgical treatment of liver oligo-PDAC and conventional systemic chemotherapy.

Materials and methods: A systematic review and meta-analysis were conducted using the PubMed and Scopus databases to identify studies comparing surgery and systemic chemotherapy in terms of long-term survival in oligo-PDAC patients. The search included studies published up to October 2024. The meta-analysis was performed using the Jamovi software.

Results: Eleven retrospective studies were selected for a total of 897 patients: 565(63%) underwent synchronous resection of liver metastases and the primary tumor, while 332(37%) received conventional chemotherapy. The majority of patients presented a pancreatic head tumor, and the median number of liver metastases ranged between 1 and 3 in the surgical cohort and 1 and 2 in the non-surgical cohort. The rate of major surgical complications was 14.4% while the cumulative incidence of post-operative mortality was 2.8%. The median overall survival(OS) in the surgical group ranged from 7.6 to 18.4 months, while a lower value comprised between 6 and 9.9 months was evidenced in the non-surgical cohort. Six studies were included in the meta-analysis for the OS evaluation, showing significantly better survival outcomes in the surgical group (OR: 0.286, 95% CI: 0.100-0.409; p <0.0001). According to the Q-test, there was no significant heterogeneity in the true outcomes (Q = 4.063, p = 0.541, I2 = 0 %). A sensitivity analysis, conducted by excluding one study at a time, confirmed the robustness of the meta-analysis findings.

Conclusions: Surgical resection of oligo-PDAC may represent a valuable treatment option with potential long-term survival benefits. However, prospective randomized trials are required to further validate these findings.

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来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
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