Si-Yi Tan, Dian-Feng Liu, Wei-Qi Wang, Bing-Song Wang
{"title":"Effect of pharmacological pupil changes on intraocular lens power calculation: a systematic review and Meta-analysis.","authors":"Si-Yi Tan, Dian-Feng Liu, Wei-Qi Wang, Bing-Song Wang","doi":"10.18240/ijo.2025.03.20","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effect of pharmacological pupil alterations on intraocular lens (IOL) power calculations.</p><p><strong>Methods: </strong>A systematic review and Meta-analysis of studies published before December 2023 in the PubMed, Embase, and Cochrane library databases on the accuracy of pharmacological pupil changes on IOL power calculation was performed. The primary outcome was the results of IOL power calculations before and after the use of medications. Subgroup analyses were performed based on participants' basic characteristics, such as age, axial length (AL), and whether miosis or mydriasis were used as classification criteria for further analyses. Each eligible study was evaluated for potential risk of bias by the AHRQ assessment scale. The study was registered on PROSPERO (CRD 42024497535).</p><p><strong>Results: </strong>A total of 3062 eyes from 21 studies were eligible. There was no significant difference in the IOL power calculation before and after pharmacological pupil changes using any of the Hoffer Q (WMD=0.055, 95%CI=-0.046-0.156; <i>P</i>=0.29), SRK/T (WMD=0.003, 95%CI=-0.073-0.080; <i>P</i>=0.93), Haigis (WMD=-0.030, 95%CI=-0.176-0.116; <i>P</i>=0.69), Holladay 2 (WMD=-0.042, 95%CI=-0.366-0.282; <i>P</i>=0.80), and Barrett Universal II (WMD=0.033, 95%CI=-0.061-0.127; <i>P</i>=0.49) formulas. On the measurement of parameters related to IOL power calculation, for either miosis or mydriasis AL (<i>P</i>=0.98 and 0.29, respectively), lens thickness (<i>P</i>=0.96 and 0.13, respectively), and mean keratometry (<i>P</i>=0.90 and 0.86, respectively) did not present significant differences, while anterior chamber depth (<i>P</i>=0.07 and <0.01, respectively) and white-to-white distance (<i>P</i>=0.01 and 0.04, respectively) changed significantly between the two measurements prior and posterior. At the same time, despite there being some participants with the difference between the before and after calculations greater than 0.5 diopter, there was no significant difference in the incidence rate between these formulas.</p><p><strong>Conclusion: </strong>There is no significant effect of pharmacological pupil changes on the IOL power calculation. It will considerably reduce the visit time burden for patients who require cataract surgery.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 3","pages":"518-525"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865652/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18240/ijo.2025.03.20","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To investigate the effect of pharmacological pupil alterations on intraocular lens (IOL) power calculations.
Methods: A systematic review and Meta-analysis of studies published before December 2023 in the PubMed, Embase, and Cochrane library databases on the accuracy of pharmacological pupil changes on IOL power calculation was performed. The primary outcome was the results of IOL power calculations before and after the use of medications. Subgroup analyses were performed based on participants' basic characteristics, such as age, axial length (AL), and whether miosis or mydriasis were used as classification criteria for further analyses. Each eligible study was evaluated for potential risk of bias by the AHRQ assessment scale. The study was registered on PROSPERO (CRD 42024497535).
Results: A total of 3062 eyes from 21 studies were eligible. There was no significant difference in the IOL power calculation before and after pharmacological pupil changes using any of the Hoffer Q (WMD=0.055, 95%CI=-0.046-0.156; P=0.29), SRK/T (WMD=0.003, 95%CI=-0.073-0.080; P=0.93), Haigis (WMD=-0.030, 95%CI=-0.176-0.116; P=0.69), Holladay 2 (WMD=-0.042, 95%CI=-0.366-0.282; P=0.80), and Barrett Universal II (WMD=0.033, 95%CI=-0.061-0.127; P=0.49) formulas. On the measurement of parameters related to IOL power calculation, for either miosis or mydriasis AL (P=0.98 and 0.29, respectively), lens thickness (P=0.96 and 0.13, respectively), and mean keratometry (P=0.90 and 0.86, respectively) did not present significant differences, while anterior chamber depth (P=0.07 and <0.01, respectively) and white-to-white distance (P=0.01 and 0.04, respectively) changed significantly between the two measurements prior and posterior. At the same time, despite there being some participants with the difference between the before and after calculations greater than 0.5 diopter, there was no significant difference in the incidence rate between these formulas.
Conclusion: There is no significant effect of pharmacological pupil changes on the IOL power calculation. It will considerably reduce the visit time burden for patients who require cataract surgery.
期刊介绍：
· International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication
and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online).
This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from
WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed,
PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166.
IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific
Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO);
Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President,
Chinese Academy of Engineering.
International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of
blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of
AAO/PAAO) et al.
Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of
Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and
Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society).
Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press).
Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and
Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics).
Associate Editors-in-Chief include:
Prof. Ning-Li Wang (President Elect of APAO);
Prof. Ke Yao (President of Chinese Ophthalmological Society) ;
Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ;
Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA);
Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society);
Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA);
Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA).
IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles,
both basic and clinical papers.
Instruction is Welcome Contribution is Welcome Citation is Welcome
Cooperation organization
International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
