Education Level and Huntington's Disease Progression: A Retrospective Cohort Analysis in Western China.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-03-19 DOI:10.1002/mdc3.70047

Sirui Zhang, Yangfan Cheng, Lingyu Zhang, Yuanzheng Ma, Jiajia Fu, Tianmi Yang, Jieqiang Xia, Chunyu Li, Jean-Marc Burgunder, Huifang Shang

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引用次数: 0

Abstract

Background: Identifying the effect of modifiable socio-environmental factors on Huntington's disease (HD) symptoms onset and progression is of great value. The role of educational attainment in HD clinical characteristics has not been elucidated.

Objectives: To clarify the effect of education attainment on the age of motor symptoms onset and clinical progression of HD patients from Western China.

Methods: A total of 244 adult-onset Chinese HD patients were included in the analysis. Linear regression, Kaplan-Meier analysis, and Cox regression analysis were conducted to assess the effect of education on the disease progression in HD.

Results: Higher education level was significantly associated with slower decline in cognitive performance, as indicated by the Symbol Digit Modality Test (β = 0.339 [95% CI, 0.047, 0.632], p = 0.026), while it exhibited no association with the progression of other symptoms.

Conclusions: The present findings suggest that education attainment is associated with a milder cognitive decline in Chinese HD patients.

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)