Reviving the past for a healthier future: ancient molecules and remedies as a solution to the antibiotic crisis.

IF 2.5 4区 生物学 Q3 MICROBIOLOGY
Future microbiology Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI:10.1080/17460913.2025.2476290
Miguel Ángel Díaz-Guerrero, Israel Castillo-Juárez, Rimma Zurabian, Alejandra Valdez, Kokila Kota, Yuki Hoshiko, Ekaprana Ramesh, Mariano Martínez-Vazquez, Corina Diana Ceapă, Mariel Hernandez-Garnica, Frederic Cadet, Rodolfo García-Contreras
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引用次数: 0

Abstract

Options to combat bacterial infections are becoming scarce. We require innovative approaches to enhance the discovery of effective antimicrobials capable of combating bacteria resistant to multiple or all antibiotics. These methods should either directly eliminate resistant bacteria or indirectly influence their viability by inhibiting their virulence or reducing their resistance to antibiotics. One interesting approach is to analyze ancient remedies used to treat bacterial infections, formulate them, and test them against modern microbes. This field has recently been named "ancientbiotics." This approach allows us to leverage centuries of empirical knowledge accumulated, from traditional medicines across various ancient cultures worldwide. The strategy has already yielded promising formulations to combat the ESKAPE group of nosocomial pathogens. Additionally, molecular de-extinction, which involves genome analysis of extinct species to search for useful antimicrobials, such as peptides, offers another avenue. In this review, we compile the antimicrobial effects of ancient remedies and de-extinct molecules known to modern science and discuss possible new strategies to further harness the potential of past remedies and molecules to fight the rise of superbugs.

为更健康的未来复兴过去:古老的分子和药物作为抗生素危机的解决方案。
对抗细菌感染的选择越来越少。我们需要创新的方法,以加强发现能够对抗多种或所有抗生素耐药细菌的有效抗菌素。这些方法要么直接消灭耐药细菌,要么通过抑制其毒力或降低其对抗生素的耐药性来间接影响其生存能力。一种有趣的方法是分析用于治疗细菌感染的古代疗法,制定它们,并测试它们对现代微生物的影响。这个领域最近被命名为“古代生物”。这种方法使我们能够利用数百年来积累的经验知识,这些知识来自世界各地各种古老文化的传统医学。该战略已经产生了对抗ESKAPE医院病原体组的有希望的配方。此外,分子去灭绝(molecular de-extinction)提供了另一种途径,它涉及对灭绝物种的基因组分析,以寻找有用的抗菌剂,如肽。在这篇综述中,我们整理了现代科学已知的古代药物和灭绝分子的抗菌作用,并讨论了可能的新策略,以进一步利用过去的药物和分子的潜力来对抗超级细菌的兴起。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Future microbiology
Future microbiology 生物-微生物学
CiteScore
4.90
自引率
3.20%
发文量
134
审稿时长
6-12 weeks
期刊介绍: Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
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