{"title":"Exposure of Bisphenols (BPA, BPB and BPC) in HepG2 Cells Results in Lysosomal Dysfunction and Lipid Accumulation.","authors":"Kiran Gill, Eshika Bindal, Parul Garg, Deepak Kumar, Rajasri Bhattacharyya, Dibyajyoti Banerjee","doi":"10.1002/cbin.70017","DOIUrl":null,"url":null,"abstract":"<p><p>Nonalcoholic fatty liver disease poses a significant public health concern, as do the issues surrounding plastic usage. The bisphenols are reported to cause fat accumulation in the liver. However, literature is scanty about the effect of bisphenols on lysosomes or lysosomal functions. We predicted the interaction of bisphenols with lysosomal proteins available in the online databases using in silico tools. Molecular docking revealed that chosen Bisphenols interact with critical lysosomal proteins including lipid hydrolyzing enzymes. Following exposure of BPA, BPB and BPC to HepG2 cells fat accumulation and lysosomal functions were evaluated. Exposure to BPB and BPC results intracellular fat accumulation under experimental conditions like BPA. All three Bisphenols disturb lysosomal homeostasis perhaps by different mechanisms. Overall our results suggest that Bisphenols can also cause fat accumulation in liver by disturbing lysosomal homeostasis.</p>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biology International","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/cbin.70017","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Nonalcoholic fatty liver disease poses a significant public health concern, as do the issues surrounding plastic usage. The bisphenols are reported to cause fat accumulation in the liver. However, literature is scanty about the effect of bisphenols on lysosomes or lysosomal functions. We predicted the interaction of bisphenols with lysosomal proteins available in the online databases using in silico tools. Molecular docking revealed that chosen Bisphenols interact with critical lysosomal proteins including lipid hydrolyzing enzymes. Following exposure of BPA, BPB and BPC to HepG2 cells fat accumulation and lysosomal functions were evaluated. Exposure to BPB and BPC results intracellular fat accumulation under experimental conditions like BPA. All three Bisphenols disturb lysosomal homeostasis perhaps by different mechanisms. Overall our results suggest that Bisphenols can also cause fat accumulation in liver by disturbing lysosomal homeostasis.
期刊介绍：
Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect.
These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.
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