Correlation between hepatitis B surface antibody (anti-HBs) in maternal blood and cord blood in newborn: a study on transplacental acquired maternal antibody.

IF 2 3区医学 Q2 PEDIATRICS

BMC Pediatrics Pub Date : 2025-03-18 DOI:10.1186/s12887-025-05569-w

Yudith Setiati Ermaya, Eka Surya Nugraha, Dolvy Girawan, Nelly Amalia Risan, Muhammad Begawan Bestari, Raden Tina Dewi Judistiani, Tetty Yuniati, Dwi Prasetyo

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引用次数: 0

Abstract

Background: Hepatitis B Virus infection is a global health problem. Transplacental maternal antibodies can protect the infant early in life from infection.

Objectives: This study investigates the correlation between maternal and infant Hepatitis B surface antibodies (anti-HBs) in pairs.

Methods: This cross-sectional study measured anti-HBs in paired mother-infant samples. Blood samples were taken from the mother 3 h before delivery and from the newborn immediately after birth by cord blood, and they were then examined for anti-HBs using the Chemiluminescent Microparticle Immunoassay.

Results: Transplacental transfer of maternal anti-HBs was analyzed in 79 mother-infant pairs. Seventeen mothers (21.5%) had positive anti-HBs and all cord blood of newborns from these mothers had anti-HBs detected. Overall, there were 44 (55.7%) newborn blood cords that were positive for anti-HBs. The geometric mean of anti-HBs cord blood titers in newborns with maternal anti-HBs titers < 10, ≥10, ≥ 100, and ≥ 1,000 mIU/mL were 52.42, 193.83, 437.12, and ≥ 1,000 mIU /mL respectively. This study showed a significant correlation in anti-HBs between mother and infant cord blood (r = 0.863; p < 0,001).

Conclusions: Anti-HB antibodies measured in mother and infant cord blood were strongly correlated, demonstrating efficient transplacental antibody transfer to protect infants against Hepatitis B infection. Hepatitis B vaccination is required for mothers to obtain immunogenicity and babies to receive hepatitis B vaccination on time.

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.