A role for the insula in establishing social dominance: structural and functional MRI studies in nonhuman primates.

IF 2.9 2区 医学 Q2 NEUROSCIENCES
Paul W Czoty, Mohammad Kawas, Kedar Madi, Richard Barcus, Jeongchul Kim, Jeremy P Hudson, Lindsey K Galbo-Thomma, Hongyu Yuan, James B Daunais, Christopher T Whitlow
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引用次数: 0

Abstract

Awareness of one's position in the social hierarchy is essential for survival. Conversely, poor social cognition is associated with several neuropsychiatric diseases. Although brain regions that mediate understanding of the social hierarchy are poorly understood, recent evidence implicates the insula. Magnetic resonance imaging (MRI) scans were acquired in twelve individually housed male cynomolgus monkeys to determine whether structural and functional characteristics of the insular cortex predicted the social rank that monkeys would attain once they formed stable social hierarchies. Structural MRI revealed that left insular volume was significantly larger in monkeys that would become dominant vs. subordinate. No differences were observed in other areas including amygdala, caudate nucleus, or prefrontal cortex. Volumetric differences were localized to dorsal anterior regions of both left and right insulae. Functional MRI revealed that global correlation, a measure of connectedness to the rest of the brain, was significantly lower in the left insula of monkeys who would become dominant vs. subordinate. Moreover, the fractional amplitude of low-frequency fluctuations, a reflection of spontaneous brain activity, trended lower in bilateral insula in the future dominant monkeys. This prospective study provides evidence for a role of the insula in the establishment and maintenance of social dominance relationships.

脑岛在建立社会支配地位中的作用:非人类灵长类动物的结构和功能MRI研究。
意识到自己在社会等级中的地位是生存所必需的。相反,社会认知能力差与一些神经精神疾病有关。尽管人们对调节社会等级理解的大脑区域知之甚少,但最近的证据表明,脑岛是其中的一部分。研究人员对12只单独饲养的雄性食蟹猴进行了核磁共振成像(MRI)扫描,以确定岛叶皮层的结构和功能特征是否能预测猴子在形成稳定的社会等级后所达到的社会等级。结构MRI显示,猴子的左岛体积明显大于将成为主导的猴子。在包括杏仁核、尾状核或前额皮质在内的其他区域没有观察到差异。体积差异局限于左右脑岛背前部区域。功能性核磁共振成像(Functional MRI)显示,在即将成为主导性和从属性的猴子中,整体相关性(衡量与大脑其他部分的连通性)在左脑岛明显较低。此外,反映自发脑活动的低频波动的分数振幅在未来优势猴的双侧脑岛呈较低趋势。这项前瞻性研究为脑岛在建立和维持社会支配关系中的作用提供了证据。
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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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