One-pot synthesis of diaroyl benzothiepine-1,1-dioxides†

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-03-11 DOI:10.1039/D5OB00198F

Meng-Yang Chang and Nai-Chen Hsueh

引用次数: 0

Abstract

We report the one-pot two-step synthesis of diaroyl benzothiepine-1,1-dioxides via rongalite-mediated double sulfination of α-bromoacetophenones followed by double condensation of the resulting 1,3-diaroyl sulfones and o-phthalaldehydes. In the (1C + 1C + 1S + 4C) reaction process, a seven-membered ring system could be constructed by two carbon–sulfur (C–S) single bonds and two carbon–carbon double bonds (CC) under mild conditions. A related putative mechanism is proposed and discussed in this article.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.