An Antibacterial Hydrogel Based on Silk Sericin Cross-Linking Glycyrrhizic Acid and Silver for Infectious Wound Healing

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-04-14 DOI:10.1021/acs.biomac.4c01687

Xiang Li , Yurong Li , Akoumay Tehoungue , Qianyan Wang , Hui Yan , Guozheng Zhang , Yeshun Zhang

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Abstract

Bioactive hydrogels are garnering increasing interest in wound management due to their porous structural features and versatile intrinsic biological activities. Importantly, the antibacterial capacity is a crucial requirement for hydrogel dressings in chronically infected wounds. In this study, we report an antibacterial hydrogel constructed from silk sericin (SS) cross-linked with glycyrrhizic acid (GA) and integrated with silver ions (Ag⁺) to accelerate the healing of bacterial-infected wounds. The resultant sericin-glycyrrhizic acid-Ag⁺ hydrogel (SGA) demonstrates favorable mechanical properties, effectively preventing secondary injury to wounds. Moreover, in vitro studies indicated that the SGA hydrogel possesses excellent swelling ratios, degradability, and cytocompatibility, promoting cell growth and proliferation. Notably, the SGA hydrogel exhibited effective antibacterial activity against both Gram-positive and Gram-negative bacteria through the release of Ag⁺. In a Staphylococcus aureus-infected wound model, the SGA hydrogel efficiently eradicated bacteria, thus promoting wound repair. Overall, our work establishes a novel strategy for developing multifunctional hydrogel dressings based on natural materials for managing bacteria-infected wounds.

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查看原文本刊更多论文

基于丝胶交联甘草酸和银的感染性伤口愈合抗菌水凝胶。

生物活性水凝胶由于其多孔结构特征和多用途的内在生物活性，在伤口管理中越来越受到关注。重要的是，抗菌能力是水凝胶敷料在慢性感染伤口的关键要求。在这项研究中，我们报道了一种由丝胶蛋白（SS）与甘草酸（GA）交联并与银离子（Ag+）结合构建的抗菌水凝胶，以加速细菌感染伤口的愈合。所得丝胶-甘草酸-银+水凝胶（SGA）具有良好的力学性能，可有效防止伤口的继发性损伤。此外，体外研究表明，SGA水凝胶具有良好的溶胀率、可降解性和细胞相容性，促进细胞生长和增殖。值得注意的是，SGA水凝胶通过释放Ag+对革兰氏阳性和革兰氏阴性细菌均表现出有效的抗菌活性。在金黄色葡萄球菌感染的伤口模型中，SGA水凝胶有效地根除细菌，从而促进伤口修复。总之，我们的工作建立了一种基于天然材料的多功能水凝胶敷料的新策略，用于治疗细菌感染的伤口。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.