Efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes: A systematic review and meta-analysis

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-03-07 DOI:10.1016/j.isci.2025.112182

Jingru Zhuang (庄静茹) , Ying Ren (任颖) , Minmin Chen (陈敏敏) , Minghui Yue (岳明辉) , Changyong Yuan (袁长永) , Rongquan Duan (段荣泉)

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引用次数: 0

Abstract

Our meta-analysis aimed to evaluate the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes. PubMed, Cochrane Library, Embase, and Web of Science were comprehensively searched until 4 December 2024, and 10 randomized controlled trials (RCTs) were included. The results indicated that, compared to the control group, localized sustained-release drugs significantly reduced probing depth (PD) (SMD = −0.77, 95% confidence interval [CI] (−1.37, −0.16)) but did not reduce clinical attachment loss (CAL) (SMD = −0.18, 95% CI (−0.60, 0.23)), sites with glycated hemoglobin (HbA1c) (SMD = 0.03, 95% CI (−0.38, 0.43)), plaque index (SMD = −0.37, 95% CI (−0.80, 0.06)), sites with bleeding on probing (BOP) (SMD = −0.26, 95% CI (−0.68, 0.16)), and gingival index (SMD = 0.07, 95% CI (−0.30, 0.44)). Subgroup analysis by different drugs elicited that, compared to the control treatment, chlorhexidine was effective in reducing BOP% (SMD = −0.55, 95% CI (−0.90, −0.19)). Our meta-analysis finds that the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes is limited.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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