Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes.

IF 16.6

Diabetes care Pub Date : 2025-05-01 DOI:10.2337/dc24-1825

Aleksi Tarkkonen, Iiris Kyläheiko, Jussi Inkeri, Marika I Eriksson, Lena M Thorn, Paula A Summanen, Turgut Tatlisumak, Per-Henrik Groop, Jukka Putaala, Daniel Gordin, Juha Martola

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Abstract

Objective: To investigate the potential progression rate of cerebral small vessel disease (CSVD) in brain MRI among neurologically asymptomatic middle-aged individuals with type 1 diabetes.

Research design and methods: A total of 172 individuals with type 1 diabetes were re-examined with brain MRI 7.5 years after their initial visit. Baseline predictors of changes in CSVD, particularly cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs) were analyzed.

Results: The proportion of individuals with type 1 diabetes with CSVD increased from 36% to 70% (P < 0.001), CMBs increased from 17% to 33% (P < 0.001), and WMHs from 23% to 63% (P < 0.001) at follow-up. The increase in CMBs was associated with baseline systolic blood pressure, HbA1c, and preexisting CMBs. The increases in CSVD and WMHs were associated only with age.

Conclusions: The prevalence of CSVD doubled over a 7.5-year period in middle-aged individuals with type 1 diabetes.

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无神经症状的中年1型糖尿病患者脑血管疾病的进展

研究目的调查神经系统无症状的1型糖尿病中年人脑磁共振成像中脑小血管病（CSVD）的潜在进展率：在首次就诊 7.5 年后，对 172 名 1 型糖尿病患者进行了脑磁共振成像复查。分析了CSVD变化的基线预测因素，尤其是脑微小出血（CMB）和白质高密度（WMH）：结果：随访时，1型糖尿病患者中患有CSVD的比例从36%增至70%（P<0.001），CMBs从17%增至33%（P<0.001），WMHs从23%增至63%（P<0.001）。CMBs的增加与基线收缩压、HbA1c和原有的CMBs有关。CSVD和WMHs的增加仅与年龄有关：结论：在7.5年的时间里，1型糖尿病中年人的CSVD患病率增加了一倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes care

CiteScore

29.50

自引率

0.00%

发文量