Targeted Partial Reprogramming as a Novel Therapeutic Strategy for Age-Related Decline.

Abstract

Cellular reprogramming has emerged as a promising strategy for the amelioration of age-associated cellular phenotypes. In-vivo reprogramming approaches, however, have been limited by a lack of specificity and oncogenic risk. Recent breakthroughs have addressed these limitations, constituting a significant progression toward the development of safe and effective therapeutics for age-related pathologies.