Clinical and Paraclinical Characteristics and Predictive Factors of Chronic Obstructive Pulmonary Exacerbation.

Materia socio-medica Pub Date : 2025-01-01 DOI:10.5455/msm.2025.37.32-36

Hoang Thuy, Nguyen Dinh Tien, Nguyen Thi Huong Giang, Nguyen Thi Nguyet, Nguyen Ngoc Nghia, Tran Thi Ly

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Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a common global condition, yet real-world data on exacerbations in Vietnamese patients remains limited. This highlights the need for further exploration of clinical complexities in this population.

Objective: The aim of this study was to characterize the clinical and paraclinical features of COPD and identify predictors of exacerbation.

Methods: A cross-sectional, prospective study was conducted on 180 inpatients at Vietnam National Lung Hospital from January 2016 to June 2021. Clinical and paraclinical data were collected.

Results: The mean patient age was 69.38 ± 9.40 years, with 92.8% male. Common symptoms included dyspnea (97.8%), cough (85.6%), and expectoration (80.0%). GOLD stage distribution was: GOLD III (53.7%), GOLD IV (29.3%), and GOLD II (17.0%). Significant predictors of exacerbation included smoking (OR=2.79), comorbidities (OR=3.95), increased dyspnea (OR=14.83), increased sputum (OR=3.13), decreased alveolar murmur (OR=4.11), wheezing (OR=2.70), white blood cell count ≥10 G/L (OR=4.79), GOLD group D (OR=9.75), and FEV1 <30% (GOLD IV) (OR=7.51) (p < 0.05).

Conclusion: Clinical and paraclinical predictors can aid in forecasting and mitigating COPD exacerbations.

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背景：慢性阻塞性肺病（COPD）是一种全球常见疾病，但越南患者病情加重的实际数据仍然有限。这凸显了进一步探索这一人群临床复杂性的必要性：本研究旨在描述慢性阻塞性肺病的临床和辅助临床特征，并确定病情加重的预测因素：2016年1月至2021年6月，越南国立肺科医院对180名住院患者进行了横断面前瞻性研究。结果：患者平均年龄为 69.38 岁：患者平均年龄为（69.38±9.40）岁，92.8%为男性。常见症状包括呼吸困难（97.8%）、咳嗽（85.6%）和痰多（80.0%）。GOLD 阶段分布为GOLD III 期（53.7%）、GOLD IV 期（29.3%）和 GOLD II 期（17.0%）。病情加重的重要预测因素包括吸烟（OR=2.79）、合并症（OR=3.95）、呼吸困难加重（OR=14.83）、痰液增多（OR=3.13）、肺泡杂音减少（OR=4.11）、喘息（OR=2.70）、白细胞计数≥10 G/L（OR=4.79）、GOLD D 组（OR=9.75）和 FEV1 结论：临床和准临床预测因子有助于预测和缓解慢性阻塞性肺疾病的恶化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materia socio-medica

CiteScore

1.80

自引率

0.00%

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