The role of lipid-soluble vitamins on glucose transporter.

Abstract

Glucose is the primary source of energy for most of the cells and essential for basic functionalities of life's biochemical processes. Transportation of glucose via biological membranes is essential for life mediated by glucose transporters (GLUT) through facilitated diffusion. Glucose transporters perform a crucial role in maintaining normal health as they transfer the most essential molecules of life, glucose. There are 14 various types of glucose transporters that transport primarily glucose and fructose. GUTTs are trans-membrane proteins expressed in the plasma membrane that facilitate the entry of carbohydrate molecules inside the cells. These transporters provide the passage for the carbohydrate molecules, which undergo oxidation inside the cells and provide essential energy in the form of ATPs. Lipid-soluble vitamins, namely A, D, E, and K have been reported to play a key role in stimulating several glucose transporters. Supplementation of lipid-soluble vitamins stimulates the expression of glucose transporters, most importantly GLUT4, GLUT2, GLUT1, and GLUT3, which play a critical role in regulating glucose metabolism in muscle, liver, brain, and RBCs. For their ability to increase the expression of GLUTs, the lipid-soluble vitamins can be the potential micronutrient for combating various non-communicable diseases. The present article discusses the essential role of lipid-soluble vitamins in the regulation of glucose transporters.