[Analysis of the correlation between serum magnesium levels and ineffective recanalization after mechanical thrombectomy in patients with acute large vessel occlusion stroke].

Abstract

Three hundred and twelve acute large vessel occlusion stroke patients who underwent mechanical thrombectomy at Changshu Hospital of Traditional Chinese Medicine, Suzhou Ninth People's Hospital, and the Second Affiliated Hospital of Soochow University from July 2016 to December 2023 were retrospectively collected. The patients were divided into effective recanalization group(mRS<3) and ineffective recanalization (mRS≥3) group based on 90-day modified Rankin scale(mRS) scores. Serum magnesium levels were categorized into tertiles: T1(Mg²⁺≤0.75 mmol/L), T2(0.75 mmol/L2+≤0.84 mmol/L) and T3(Mg²⁺>0.84 mmol/L), and the relationship between serum magnesium levels and ineffective recanalization was evaluated. Multivariable logistic regression model was used to analyze the related factors of ineffective recanalization. Low serum magnesium levels (Mg²⁺≤0.75 mmol/L) (OR=1.94, 95%CI: 1.03-3.64), previous stroke history (OR=2.22, 95%CI: 1.04-4.75), pre-procedural hyperglycemia (OR=1.16, 95%CI: 1.05-1.29), and lower Alberta stroke early CT scores(ASPECTS) (OR=0.38, 95%CI: 0.20-0.72) were related risk factors for ineffective recanalization after mechanical thrombectomy. The proportion of patients with mRS scores of≥3 was highest in the T1 group [65.1% (71/109)] and lowest in the T3 group [51.0% (49/96)]. Serum magnesium level is closely related to functional prognosis of patients.