Herpes simplex virus 2-induced aseptic meningitis presenting with sudden deafness: A case report.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

World Journal of Clinical Cases Pub Date : 2025-03-16 DOI:10.12998/wjcc.v13.i8.98320

Yuan-Cheng Liu, Shih-Hsuan Hsiao, Peir-Rong Chen

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引用次数: 0

Abstract

Background: Aseptic meningitis is defined as meningeal inflammation caused by various etiologies with negative cerebrospinal fluid (CSF) bacterial culture. The most common etiologies are viruses [enteroviruses, arboviruses, and herpes simplex virus type 2 (HSV-2)]. Aseptic meningitis can have various presentations, including sensorineural deafness. While sensorineural deafness from mumps meningoencephalitis has been reported, cases of HSV-2-induced hearing loss are rare. Herein, we report a case of HSV-2-induced meningitis that presented with sudden deafness.

Case summary: A 68-year-old man experienced a profound sudden onset of left-sided hearing loss for one day. Pure-tone audiograms demonstrated sudden left-sided sensorineural hearing loss (thresholds 80-90 dB). After treatment with high-dose steroids for 1 week, he experienced an acute consciousness change with left hemiparesis. The laboratory data showed no significant abnormalities. Brain computed tomography without contrast and magnetic resonance imaging revealed no intracranial hemorrhage or obvious brain lesion. The CSF analysis and the Multiplex PCR panels showed HSV-2 positivity. Hence, under the diagnosis of herpes meningoencephalitis, acyclovir was prescribed and his symptoms gradually resolved.

Conclusion: This case report further demonstrates that a viral infection could be a cause of sudden sensorineural hearing loss.

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单纯疱疹病毒2型引起的无菌性脑膜炎并发突发性耳聋1例。

背景：无菌性脑膜炎被定义为脑脊液（CSF）细菌培养阴性的各种病因引起的脑膜炎症。最常见的病因是病毒[肠病毒、虫媒病毒和2型单纯疱疹病毒（HSV-2）]。无菌性脑膜炎可以有多种表现，包括感音神经性耳聋。虽然有由流行性腮腺炎脑膜脑炎引起的感音神经性耳聋的报告，但单纯疱疹病毒-2引起的听力损失病例很少。在此，我们报告一例hsv -2引起的脑膜炎，表现为突发性耳聋。病例总结：一名68岁男性在一天内经历了严重的左侧突发性听力损失。纯音听力图显示左侧突发性感音神经性听力损失（阈值80- 90db）。大剂量类固醇治疗1周后，患者出现急性意识改变，伴有左偏瘫。实验室数据未见明显异常。脑ct及磁共振未见颅内出血及明显脑损伤。脑脊液分析和多重PCR结果显示HSV-2阳性。因此，在诊断为疱疹性脑膜脑炎的情况下，给他开了阿昔洛韦，症状逐渐消失。结论：本病例报告进一步证明病毒感染可能是突发性感音神经性听力损失的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Clinical Cases Medicine-General Medicine

自引率

0.00%

发文量

3384

期刊介绍： The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.