Analysis of HIV-1 subtypes and drug resistance mutations in people who inject drugs in Aizawl and nearby districts of Mizoram, India.

IF 5.4 1区 农林科学 Q1 IMMUNOLOGY
Virulence Pub Date : 2025-12-01 Epub Date: 2025-03-18 DOI:10.1080/21505594.2025.2478074
Komal Raskar, Lal Thlengliani, Andrew Lalbiaknunga, Dipali Kale, Ajit Patil, Pragati Chavan, Richard Clr Hluna, Samiran Panda, Swarali Kurle
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Abstract

Over the last decade, there has been a steady increase in HIV-1 prevalence in Mizoram, India. Importantly, this increase in HIV-1 prevalence is not only limited to the key population groups such as female sex workers (FSWs) or people who inject drugs (PWID), and has been witnessed in general population as well. Injecting drug use has long been one of the key drivers of HIV-1 epidemic across the north-eastern states of India. In this study, using HIV-1 pol gene region sequences from Aizawl and adjoining districts, we examined the HIV-1 subtypes, recombinant forms, drug resistance mutations and also the spatiotemporal dynamics of the potential unique recombinant forms. In our dataset, the dominant subtype was HIV-1 subtype C (94.91%). We could also identify the presence of CRF01_AE (1.69%) and BC recombinant forms (3.39%). Drug resistance mutation analysis revealed that resistance against non-nucleoside reverse transcriptase inhibitors was most common in the sequences having any resistance mutations. Evolutionary analysis of unique BC recombinants estimated the most recent common ancestor of these sequences around 2004-2005 and them having an ancestry of United States of America (USA) origin.

印度米佐拉姆邦Aizawl及附近地区注射吸毒者中HIV-1亚型和耐药突变分析
在过去十年中,印度米佐拉姆邦的艾滋病毒-1流行率稳步上升。重要的是,艾滋病毒-1流行率的增加不仅限于女性性工作者(FSWs)或注射吸毒者(PWID)等关键人群,而且在一般人群中也可以看到。注射吸毒长期以来一直是印度东北部各邦艾滋病毒-1流行的主要驱动因素之一。本研究利用Aizawl及其邻近地区的HIV-1 pol基因区域序列,研究了HIV-1亚型、重组形式、耐药突变以及潜在独特重组形式的时空动态。在我们的数据集中,主要亚型是HIV-1亚型C(94.91%)。我们还鉴定出CRF01_AE(1.69%)和BC重组形式(3.39%)的存在。耐药突变分析显示,在具有耐药突变的序列中,对非核苷类逆转录酶抑制剂的耐药最为常见。对独特的BC重组的进化分析估计,这些序列最近的共同祖先大约在2004-2005年,它们的祖先来自美利坚合众国。
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来源期刊
Virulence
Virulence IMMUNOLOGY-MICROBIOLOGY
CiteScore
9.20
自引率
1.90%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.
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