The Effects of Polyphenols on Doxorubicin-Induced Nephrotoxicity by Modulating Inflammatory Cytokines, Apoptosis, Oxidative Stress, and Oxidative DNA Damage.

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Phytotherapy Research Pub Date : 2025-05-01 Epub Date: 2025-03-16 DOI:10.1002/ptr.8470
Lang Wang, Can Wei, Junfeng Jing, Mingmin Shao, Zhen Wang, Bo Wen, Mingming Lu, Zhenzhen Jia, Yanbin Zhang
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引用次数: 0

Abstract

Doxorubicin (DOX) is an anthracyclic antibiotic with anti-neoplastic activity that has been found to be a highly effective and commonly used chemotherapeutic agent in the treatment of a variety of solid and hematologic malignancies. However, its effectiveness has been limited by the occurrence of dose-related renal, myocardial, and bone marrow toxicities. The clinical use of DOX is associated with nephrotic syndrome characterized by heavy proteinuria, hypoalbuminemia, and hyperlipidemia. DOX-induced changes in the renal tissue of rats include increased glomerular capillary permeability and tubular atrophy. Several lines of evidence suggest that reactive oxygen species and oxidative stress have been associated with DOX-induced renal damage. The mechanism of DOX-induced nephrotoxicity is believed to be mediated through free radical formation, iron-dependent oxidative damage of biological macromolecules, and membrane lipid peroxidation. Polyphenols are present in high concentration in fruits and vegetables. They have been shown to have potent antioxidant and cytoprotective effects in preventing endothelial apoptosis caused by oxidants. Treatment with polyphenols has been shown to prevent liver damage and suppress overexpression of inducible nitric oxide synthase, which is induced by various inflammatory stimuli. In addition, epidemiological studies have suggested that the intake of polyphenols may be associated with a reduced risk of DOX-induced nephrotoxicity by modulating inflammatory cytokines, apoptosis, oxidative stress, and oxidative DNA damage. Therefore, in the present review, we examined the influence of polyphenols on DOX-induced nephrotoxicity.

多酚通过调节炎症细胞因子、细胞凋亡、氧化应激和氧化DNA损伤对阿霉素诱导的肾毒性的影响。
阿霉素(DOX)是一种具有抗肿瘤活性的蒽环类抗生素,已被发现是一种非常有效和常用的化疗药物,用于治疗各种实体和血液系统恶性肿瘤。然而,其有效性受到剂量相关的肾、心肌和骨髓毒性的限制。DOX的临床使用与以蛋白尿、低白蛋白血症和高脂血症为特征的肾病综合征有关。dox诱导的大鼠肾组织变化包括肾小球毛细血管通透性增加和肾小管萎缩。多项证据表明,活性氧和氧化应激与dox诱导的肾损伤有关。dox诱导肾毒性的机制被认为是通过自由基形成、铁依赖性生物大分子氧化损伤和膜脂过氧化介导的。多酚在水果和蔬菜中含量很高。它们已被证明具有有效的抗氧化和细胞保护作用,防止由氧化剂引起的内皮细胞凋亡。多酚治疗已被证明可以预防肝损伤和抑制诱导型一氧化氮合酶的过度表达,这是由各种炎症刺激诱导的。此外,流行病学研究表明,摄入多酚可能通过调节炎症细胞因子、细胞凋亡、氧化应激和氧化性DNA损伤,与dox诱导的肾毒性风险降低有关。因此,在本综述中,我们研究了多酚对dox引起的肾毒性的影响。
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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