Effects of Dietary Polyphenols on Vasculogenic Erectile Dysfunction: A Systematic Review of Pre-Clinical Studies.

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Rafaela Geraldo, Catarina Castro, Elisabete Pinto, Marta W Vasconcelos, Delminda Neves
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引用次数: 0

Abstract

Erectile dysfunction (ED) is a medical condition characterized by the inability to achieve or maintain a satisfactory erection, primarily treated with oral phosphodiesterase type 5 inhibitors. Treatment effectiveness is diminished in severe vasculogenic ED, particularly in patients with diabetes mellitus, highlighting the need for exploring alternative/complementary interventions. Among them, dietary phenolic compounds are known for their antioxidant and anti-inflammatory properties. This systematic review focuses on catechin (EGCG), quercetin, resveratrol, and curcumin and their influence on the pathophysiology of ED. Following PRISMA 2020 guidelines (PROSPERO registration number CRD42023402016) searches across PubMed, Scopus, and Web of Science until October 2024 were conducted using relevant keywords. Inclusion criteria required original articles in English, while in silico studies, review articles, editorials, and original studies lacking essential polyphenol administration information were excluded. After an initial search that located 409, 445, and 285 publications in each database respectively, rigorous screening resulted in 26 publications comprising animal, ex vivo, and in vitro studies. Their quality was assessed using GRADE and SYRCLE ROB tools, revealing an overall "medium-high" or "high quality." These polyphenols consistently demonstrated improvements in erectile function, encompassing behavioral, functional, molecular, and hormonal aspects. However, limitations were identified, such as the predominant reliance on animal models and in vitro trials, which may not precisely reflect human physiological responses. Further clinical investigations are needed to ascertain data translational potential, standardize dosages, and establish safe and effective prescription recommendations. Prioritizing clinical trials is essential for validating the widespread applicability and efficacy of polyphenols in managing ED.

膳食多酚对血管源性勃起功能障碍的影响:临床前研究的系统综述。
勃起功能障碍(ED)是一种以无法达到或维持令人满意的勃起为特征的医学病症,主要通过口服磷酸二酯酶5型抑制剂治疗。严重血管源性ED的治疗效果下降,特别是糖尿病患者,这突出了探索替代/补充干预措施的必要性。其中,膳食酚类化合物以其抗氧化和抗炎特性而闻名。本系统综述的重点是儿茶素(EGCG)、槲皮素、白藜芦醇和姜黄素及其对ED病理生理的影响。遵循PRISMA 2020指南(PROSPERO注册号CRD42023402016),使用相关关键词在PubMed、Scopus和Web of Science上进行检索,直到2024年10月。纳入标准要求为英文原创文章,而缺乏必要多酚给药信息的硅片研究、综述文章、社论和原创研究被排除在外。在对每个数据库中的409篇、445篇和285篇出版物分别进行初步检索后,经过严格筛选,得出26篇出版物,包括动物、离体和体外研究。它们的质量使用GRADE和sycle ROB工具进行评估,显示整体的“中高”或“高质量”。这些多酚持续改善勃起功能,包括行为、功能、分子和激素方面。然而,也发现了局限性,例如主要依赖于动物模型和体外试验,这可能无法准确反映人类的生理反应。需要进一步的临床研究来确定数据的转化潜力,标准化剂量,并建立安全有效的处方建议。优先进行临床试验对于验证多酚在治疗ED中的广泛适用性和有效性至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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