Anti-MRSA and cytotoxic activity of a new diamide compound isolated from Aspergillus sp. H30.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-03-17 DOI:10.1080/14786419.2025.2478529

Long-Fen Li, Ying-Ying Hu, Xin-Zhu Wang, Qing-Zhou Meng, Pei-Pei Zhao, Qiao-Ni Chen, Ying Xu, Xue-Kui Xia

引用次数: 0

Abstract

A new aromatic diamide compound, aspergillusin A (1), together with three known compounds, globosterol (2), ergosterol (3), and cladosporide A (4), was isolated from the crude extract of the endophytic fungi Aspergillus sp. H30. The structures were elucidated using NMR and MS data, finally, the biosynthetic pathway of compound 1 was hypothesised. Compounds 1-4 were tested for their antibacterial activities on six pathogenic bacteria and compound 1 was also evaluated against human non-small cell lung cancer H1299. Among them, compound 1 exhibited weak antibacterial activity against MRSA and a strong effect against the human bronchial epithelial cell line, BEAS-2B, with an IC₅₀ value of 12.32 ± 0.37 μM.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.