Effects of experimental hepatic steatosis on apelin and various biochemical parameters in male white rabbits.

Abstract

Background: Hepatic steatosis is the second most prevalent liver disease following viral hepatitis, and its incidence is increasing rapidly, posing a significant threat to human health.

Aim: This research aimed to identify natural treatment methods that reduce the risk of experimental hepatic steatosis with triton by answering the following questions:Do polyphenols extracted from strawberries reduce the risk of experimental hepatic steatosis in rabbits?Do omega-3 extracted from almonds reduce the risk of experimental hepatic steatosis in rabbits?Is giving Omega-3, Vit. E considered the optimal treatment for hepatic steatosis?

Methods: This study aimed to assess the effects of strawberry polyphenols, omega-3 from almonds, omega-3, and vitamin E on reducing the risk of Triton-induced liver steatosis. The experiment involved 100 male rabbits (10-12 months old, 1,150-1,350 g) divided randomly into the following 10 groups: control group, Triton (300 mg/kg body mass) group, strawberry polyphenols group, strawberry polyphenols with Triton group, almond Omega-3 group, almond Omega-3 with Triton group, strawberry polyphenols with almond Omega-3 group, strawberry polyphenols with almond Omega-3 with Triton group, Omega-3, Vit. E group, and Omega-3, Vit. E with Triton group. Dosing occurred daily for 4 months.

Results: The results of the study indicated a significant increase in the levels of Triglycerides, Total cholesterol, Low-density lipoprotein-cholesterol, and Very low-density lipoprotein-cholesterol in the group of rabbits treated with Triton compared with the other groups, while these parameters decreased in the groups treated with strawberry polyphenols, omega-3 from almonds, omega-3, and vitamin E. In addition, the levels of High-density lipoprotein-cholesterol, Paroxinase-1 activity, and apelin concentration decreased in the group treated with Triton but increased in the groups receiving strawberry polyphenols, omega-3 from almonds, omega-3, and vitamin E, at a probability level (p ≤ 0.01).

Conclusion: These results suggest that polyphenols extracted from strawberries, Omega-3 extracted from almonds, and Omega-3, Vit. E is a suitable treatment for hepatic steatosis.