Ferroptosis: A New Challenge and Target in Oral Diseases.

IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Oral diseases Pub Date : 2025-03-17 DOI:10.1111/odi.15303
Ruijie Jiao, Hu Long
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引用次数: 0

Abstract

Objective: Ferroptosis, an iron-dependent intracellular programmed cell death mechanism discovered in the last decade, has emerged as a novel and intriguing concept in oral diseases, distinct from apoptosis, necrosis, and pyroptosis. This process plays a critical role in the pathophysiology of inflammation, trauma, and tumors, with evidence of its presence in multiple organ systems, including the liver, kidneys, and heart. In recent years, many studies have found that ferroptosis is closely related to oral diseases, and a number of pathogenic pathways and therapeutic strategies have been reported. However, ferroptosis remains an underexplored area in oral diseases, with multiple secrets waiting to be uncovered.

Method: We collected articles related to ferroptosis and oral diseases and analyzed the mechanisms and therapeutic strategies associated with ferroptosis in different oral diseases.

Results: In this review, we present a comprehensive analysis of ferroptosis and oral diseases, emphasizing its core mechanisms and associated therapeutic approaches. Furthermore, we give an outlook for future explorations of ferroptosis related to oral diseases.

Conclusion: This review provides dental researchers and clinicians with a current state of ferroptosis in oral diseases, thereby inspiring noval investigations and discoveries.

上睑下垂:口腔疾病的新挑战和新目标。
目的:铁坏死(Ferroptosis)是近十年来发现的一种铁依赖性细胞内程序性细胞死亡机制,是口腔疾病中一个不同于细胞凋亡、坏死和焦亡的新颖而有趣的概念。这一过程在炎症、创伤和肿瘤的病理生理中起着关键作用,有证据表明它存在于多个器官系统,包括肝脏、肾脏和心脏。近年来,许多研究发现铁下垂与口腔疾病密切相关,并报道了许多致病途径和治疗策略。然而,在口腔疾病中,铁下垂仍然是一个未被充分探索的领域,有许多秘密等待被揭开。方法:收集有关铁下垂与口腔疾病的相关文献,分析不同口腔疾病中铁下垂的发病机制及治疗策略。结果:本文综合分析了铁下垂与口腔疾病的关系,强调了其核心机制和相关治疗方法。此外,我们对与口腔疾病相关的铁下垂的未来探索进行了展望。结论:本文综述了口腔疾病中铁下垂的现状,从而激发了新的研究和发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Oral diseases
Oral diseases 医学-牙科与口腔外科
CiteScore
7.60
自引率
5.30%
发文量
325
审稿时长
4-8 weeks
期刊介绍: Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.
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