Mortality and clinical outcomes in paediatric septic shock: a propensity-matched analysis before and after the implementation of an institutional guideline in single centre in Thailand.

IF 1.8 4区 医学 Q2 PEDIATRICS
Natar Wajanathawornchai, Kantara Saelim, Ponlagrit Kumwichar, Kanokpan Ruangnapa, Pharsai Prasertsan, Wanaporn Anuntaseree
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引用次数: 0

Abstract

Paediatric septic shock is a life-threatening condition with high global morbidity and mortality rates. Prior guidelines for paediatric septic shock demonstrated varying levels of effectiveness. In 2017, the institutional paediatric septic shock guidelines were established, emphasizing three pivotal components: prompt recognition, early and appropriate resuscitation, and organ support with intensive stabilization. Herein, we aimed to assess the effect of paediatric septic shock guidelines on mortality and clinical outcomes. This single-centre retrospective cohort study investigating the pre- and postimplementation of paediatric septic shock guidelines was conducted in patients aged 1 month to 15 years diagnosed with septic shock from January 2014 to December 2022. The effectiveness of the guideline implementation was evaluated through propensity matching analysis to compare 30-day in-hospital mortality rates. Adherence to key components of the guidelines was also assessed. In total, 71 and 106 paediatric patients with septic shock were admitted to the paediatric intensive care unit during the pre- and postguideline periods, respectively. The postguideline group exhibited a significant reduction in mortality [adjusted odds ratio (aOR): 0.29, 95% confidence interval (CI): 0.12-0.71, P = .007] and a decrease in respiratory dysfunction (aOR: 0.40, 95% CI: 0.18-0.91, P = .03). Guideline adherence revealed a substantial increase in the use of peripheral inotropes and noninvasive cardiac monitoring. The number needed to treat for the protocol to prevent death was six. The implementation of the paediatric septic shock guidelines, emphasizing early shock recognition, prompt resuscitation, infection control, and appropriate organ management in intensive care, significantly improved outcomes.

儿童感染性休克的死亡率和临床结果:泰国单一中心实施机构指南前后的倾向匹配分析
小儿感染性休克是一种危及生命的疾病,全球发病率和死亡率都很高。先前的儿科感染性休克指南显示出不同程度的有效性。2017年,制定了机构儿科感染性休克指南,强调了三个关键组成部分:及时识别、早期适当复苏、器官支持和强化稳定。在此,我们旨在评估儿科感染性休克指南对死亡率和临床结果的影响。这项单中心回顾性队列研究调查了2014年1月至2022年12月诊断为感染性休克的1个月至15岁的儿童感染性休克指南实施前后的情况。通过倾向匹配分析比较30天住院死亡率,评估指南实施的有效性。对准则关键部分的遵守情况也进行了评估。在指南实施前和实施后,共有71例和106例感染性休克患儿入住儿科重症监护病房。指南后组显示死亡率显著降低[调整优势比(aOR): 0.29, 95%可信区间(CI): 0.12-0.71, P =。[007]呼吸功能障碍降低(aOR: 0.40, 95% CI: 0.18-0.91, P = 0.03)。指南依从性显示外周肌力和无创心脏监测的使用大幅增加。按照该方案,需要治疗以防止死亡的人数是6人。实施儿科感染性休克指南,强调早期休克识别、及时复苏、感染控制和重症监护中适当的器官管理,显著改善了结果。
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来源期刊
Journal of Tropical Pediatrics
Journal of Tropical Pediatrics 医学-热带医学
CiteScore
4.00
自引率
0.00%
发文量
97
审稿时长
6-12 weeks
期刊介绍: The Journal of Tropical Pediatrics provides a link between theory and practice in the field. Papers report key results of clinical and community research, and considerations of programme development. More general descriptive pieces are included when they have application to work preceeding elsewhere. The journal also presents review articles, book reviews and, occasionally, short monographs and selections of important papers delivered at relevant conferences.
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