{"title":"Recent Advances in Colorimetric and Fluorescent Chemosensors for Cu<sup>2</sup>⁺ Ions: Trends, Challenges, and Future Directions.","authors":"Duraisamy Udhayakumari","doi":"10.1007/s10895-025-04253-7","DOIUrl":null,"url":null,"abstract":"<p><p>The detection of copper ions (Cu<sup>2</sup>⁺) through colorimetric and fluorometric methods has garnered significant attention due to the biological, environmental, and medical importance of Cu<sup>2</sup>⁺. These detection techniques have proven to be highly effective due to their simplicity, cost-efficiency, high sensitivity, and suitability for bioimaging applications. This critical review begins by briefly addressing the sources, applications, and toxicity of copper ion sensors. It then provides an in-depth classification of fluorescent and colorimetric Cu<sup>2</sup>⁺ sensors based on their receptors, organizing them into various categories such as anthracene, pyridine, pyrazole, pyrrole, naphthalene, imidazole, and quinoline functionalized sensing systems, with a focus on developments since 2016.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorescence","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10895-025-04253-7","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
The detection of copper ions (Cu2⁺) through colorimetric and fluorometric methods has garnered significant attention due to the biological, environmental, and medical importance of Cu2⁺. These detection techniques have proven to be highly effective due to their simplicity, cost-efficiency, high sensitivity, and suitability for bioimaging applications. This critical review begins by briefly addressing the sources, applications, and toxicity of copper ion sensors. It then provides an in-depth classification of fluorescent and colorimetric Cu2⁺ sensors based on their receptors, organizing them into various categories such as anthracene, pyridine, pyrazole, pyrrole, naphthalene, imidazole, and quinoline functionalized sensing systems, with a focus on developments since 2016.
期刊介绍：
Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
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