Characteristics of dry eye associated with autoimmune diseases.

IF 2.1 3区医学 Q2 OPHTHALMOLOGY

Japanese Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2025-03-17 DOI:10.1007/s10384-025-01172-9

Ayano Yoshimura, Yuka Hosotani, Nahomi Masuda, Fumi Gomi

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引用次数: 0

Abstract

Purpose: To investigate the characteristics of dry eye in patients with autoimmune disease.

Study design: Retrospective clinical study.

Methods: Two hundred and fifty-two eyes from 252 patients (12 men and 240 women, mean age 59.8 ±15.2) with autoimmune disease and dry eye were enrolled. Patients were divided into three groups: primary Sjogren's syndrome, secondary Sjogren's syndrome, and autoimmune disease without Sjogren's syndrome.

Results: Among all cases, the mean fluorescein breakup time (FBUT) was 2.7 ± 1.6 s, the van Bijesterveld corneal score was 0.8 ± 0.8, the conjunctival score was 1.5 ± 1.7; and the Schirmer 1 test value was 8.4 ± 8.2 mm. Among all cases, the fluorescein breakup pattern (FBUPs) was tear-deficiency-type dry eye in 43% of eyes (area 11%, line 32%), and short FBUT-type dry eye in 57% (dimple 31%, spot 10%, random 16%). Conjunctival scores showed significant positive correlations with anti-SS-A and anti-SS-B antibody titers in the primary and secondary Sjogren's syndrome groups.

Conclusion: More than half of the dry eyes associated with autoimmune diseases were short FBUT-type. Patients with autoimmune disease should be aware of dry eye, even without a diagnosis of Sjogren's syndrome.

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与自身免疫性疾病相关的干眼特征。

目的：探讨自身免疫性疾病患者干眼的特点。研究设计：回顾性临床研究。方法：纳入252例自身免疫性疾病和干眼症患者（男性12例，女性240例，平均年龄59.8±15.2岁）的252只眼。患者被分为三组：原发性干燥综合征、继发性干燥综合征和无干燥综合征的自身免疫性疾病。结果：所有病例的平均荧光素破裂时间（FBUT）为2.7±1.6 s， van Bijesterveld角膜评分为0.8±0.8，结膜评分为1.5±1.7；Schirmer 1检验值为8.4±8.2 mm。在所有病例中，荧光素分解模式（FBUPs）为泪液缺乏型干眼，占43%（面积11%，线32%），短FBUPs型干眼占57%（凹窝31%，斑点10%，随机16%）。原发性和继发性干燥综合征组结膜评分与抗ss - a和抗ss - b抗体滴度呈显著正相关。结论：自身免疫性疾病相关干眼半数以上为短型fbut型。患有自身免疫性疾病的患者应该意识到干眼症，即使没有干燥综合征的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Ophthalmology 医学-眼科学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.