Progression of lymphatic filariasis antigenaemia and microfilaraemia over 4.5 years in antigen-positive individuals, Samoa 2019-2023

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-03-15 DOI:10.1016/j.ijid.2025.107891

Helen J. Mayfield , Benn Sartorius , Ramona Muttucumaru , Sarah Sheridan , Maddison Howlett , Beatris Mario Martin , Shannon M. Hedtke , Emma Field , Robert Thomsen , Satupaitea Viali , Patricia M. Graves , Colleen L. Lau

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引用次数: 0

Abstract

Objectives

The first round of triple-drug mass drug administration (MDA) for lymphatic filariasis (LF) in Samoa was in 2018. This study aims to i) examine progression of LF antigen (Ag) and microfilaria (Mf) in Ag-positive individuals from 2019-2023; and ii) compare Ag/Mf prevalence in household members of Mf-positive vs Mf-negative participants.

Methods

In 2023, we tested Ag-positive participants (indexes) from a 2019 survey in Samoa, and their household members. We tested for Ag (Alere/Abbott Filariasis Test Strip) and Mf. We examined changes in Ag/Mf status in index participants and compared Ag/Mf prevalence between household members of Mf-positive and Mf-negative indexes.

Results

We recruited 91 indexes and 317 household members. In 2023, all 17 Mf-positive indexes remained Ag-positive and 11/15 with Mf results (73.3%) were Mf-positive. Of 74 Mf-negative indexes, 79.7% remained Ag-positive in 2023 and 31.1% became Mf-positive. Household members of Mf-positive indexes were more likely to be Ag-positive (odds ratios 3.3, 95% CI 1.0-10.3) compared to those of Mf-negative indexes.

Conclusion

Our results raise concerns regarding long-term effectiveness of a single-dose of triple-drug MDA for sustained clearance of Mf in Samoa. Guidelines for follow-up and treatment of Ag/Mf-positive people and household members are urgently required.

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萨摩亚2019-2023年抗原阳性个体中淋巴丝虫病抗原血症和微丝虫病在4.5年内的进展情况

目的：萨摩亚淋巴丝虫病（LF）的第一轮三联药大规模给药（MDA）是在2018年。本研究旨在i)检测2019- 2023年Ag阳性个体LF抗原（Ag）和微丝蚴（Mf）的进展；ii)比较Mf阳性和Mf阴性参与者家庭成员的Ag/Mf患病率。方法：2023年，我们对萨摩亚2019年调查中的ag阳性参与者（指数）及其家庭成员进行了测试。我们检测了Ag （Alere/Abbott丝虫病试纸）和Mf。我们检查了指数参与者的Ag/Mf状况的变化，并比较了Mf阳性和Mf阴性指数家庭成员之间的Ag/Mf患病率。结果：共纳入91项指标和317户家庭成员。2023年，17项Mf阳性指标均为ag阳性，11/15例Mf阳性（73.3%）。74项mf阴性指标中，2023年79.7%为ag阳性，31.1%为mf阳性。与mf阴性指数的家庭成员相比，mf阳性指数的家庭成员更容易出现ag阳性（OR 3.3, 95% CI 1.0-10.3）。结论：我们的研究结果引起了人们对萨摩亚单剂量三药丙二醛持续清除Mf的长期有效性的关注。迫切需要对银/中性粒细胞阳性者和家庭成员进行随访和治疗的指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.