Evaluation of Anti-Inflammatory and Antibacterial Properties of Photo-Thermal Hydrogel as Dual Functional Platform for Management of Periodontitis.

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S508864

Zhisong Mai, Yuying Mai, Xianxian Huang, Shipeng Ning, Hongbing Liao

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引用次数: 0

Abstract

Background: Periodontitis, one of the most common oral diseases caused by bacterial infection which affects gums, periodontal ligament and alveolar bone, is a leading cause of tooth loss in adults. Current clinical treatments, such as scaling or antibiotics, often result in incomplete biofilm removal or can contribute to drug resistance.

Methods: To address these limitations, a nanozyme comprising platinum, copper, and selenium was developed, which was then incorporated into a thermoresponsive hydrogel.

Results: When applied to periodontal pockets and exposed to 808 nm laser irradiation, the hydrogel became soft, dissolving to release the nanozyme. This nanozyme demonstrated superoxide dismutase (SOD)-like and catalase (CAT)-like activity, reducing excess reactive oxygen species (ROS) while displaying strong antibacterial and anti-inflammatory effects.

Conclusion: This photothermal nanozyme hydrogel showed excellent biocompatibility and has the potential to overcome the challenges of current periodontitis treatments.

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评估光热水凝胶作为治疗牙周炎的双重功能平台的消炎和抗菌特性

背景：牙周炎是由细菌感染引起的最常见的口腔疾病之一，可影响牙龈、牙周韧带和牙槽骨，是导致成人牙齿脱落的主要原因。目前的临床治疗，如刮除或抗生素，往往导致生物膜去除不完全或可能导致耐药性。方法：为了解决这些局限性，开发了一种由铂、铜和硒组成的纳米酶，然后将其纳入热反应性水凝胶中。结果：将水凝胶涂于牙周袋内，808 nm激光照射后，水凝胶变软，溶解释放纳米酶。该纳米酶具有超氧化物歧化酶（SOD）样和过氧化氢酶（CAT）样活性，可减少过量活性氧（ROS），同时具有很强的抗菌和抗炎作用。结论：该光热纳米酶水凝胶具有良好的生物相容性，具有克服当前牙周炎治疗挑战的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.