Investigation of nonmotor symptoms and their clinical correlates in patients with Parkinson's disease.

IF 2.3 Q3 CLINICAL NEUROLOGY

Neurodegenerative disease management Pub Date : 2025-02-01 Epub Date: 2025-03-17 DOI:10.1080/17582024.2025.2468145

H Onder, S Comoglu

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Abstract

Background: In this study, we aimed to investigate the clinical features of a large group of patients with Parkinson's disease (PD), paying particular attention to the nonmotor symptom (NMS) load. Secondly, we aimed to investigate the clinical correlates of NMSs using the results of various clinical assessments.

Methods: Data from all PD patients who visited our movement disorders clinic between January 2023 and March 2024 were retrospectively reviewed. We included the data of all patients whose information regarding clinical features and extensive scale results were available.

Results: Overall, we included data from 285 PD patients with a mean age of 64.5 ± 10.0 years (F/M = 119/166). The median scores of the MDS-UPDRS subparts were 9 for MDS-UPDRS-1 and 30 for MDS-UPDRS-3 (off). The median NMSS score was 38 (range: 229), and 46% of the patients had severe to very severe disease in terms of NMS burden. The regression analyses revealed the MDS-UPDRS 3 score, FES-I score, and RBD (0.9772 + 0.453*MDS-UPDRS 3 + 0.724 * FES-I + 15.192*RBD) as predictors of the NMS scale.

Conclusions: We found a very high NMS burden in our PD cohort. Remarkably, RBD, motor stage, and concern about falling were found to correlate with NMS load.

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帕金森病患者非运动症状及其临床相关性的研究

背景：在本研究中，我们旨在研究一大组帕金森病（PD）患者的临床特征，特别关注非运动症状（NMS）负荷。其次，我们的目的是利用各种临床评估的结果来研究NMSs的临床相关性。方法：回顾性分析2023年1月至2024年3月期间到我们的运动障碍诊所就诊的所有PD患者的数据。我们纳入了所有能获得临床特征和广泛量表结果信息的患者的数据。结果：总的来说，我们纳入了285例PD患者的数据，平均年龄为64.5±10.0岁（F/M = 119/166）。MDS-UPDRS-1子部分的中位得分为9分，MDS-UPDRS-3子部分的中位得分为30分（off）。NMSS评分中位数为38（范围：229），在NMS负担方面，46%的患者患有严重到非常严重的疾病。回归分析显示，MDS-UPDRS 3评分、FES-I评分和RBD （0.9772 + 0.453*MDS-UPDRS 3 + 0.724 * FES-I + 15.192*RBD）是NMS量表的预测因子。结论：我们发现PD队列的NMS负担非常高。值得注意的是，RBD、运动阶段和对跌倒的担忧与NMS负荷相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurodegenerative disease management CLINICAL NEUROLOGY-

CiteScore

4.30

自引率

0.00%

发文量