{"title":"Number of chronic diseases and cognitive function among the elderly in China: a moderated mediation model.","authors":"Xiaoling Feng, Jie Peng, Xiaoying Cao, Lichong Lai, Dongmei Huang, Pinyue Tao, Xiao Pan, Qini Pan, Dejing Fan, Shuyu Lu, Caili Li, Yanfei Pan, Pengxin Dong, Haichen Wu, Yidan Chai, Ping Huang, Huiqiao Huang","doi":"10.3389/fpsyg.2025.1491382","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Despite the wealth of data on the role of chronic disease comorbidity in shaping cognitive dysfunction in older adults, a comprehensive view of this dynamic interplay remains a frontier. This study will reveal the intricate interactions between the number of chronic diseases and cognitive function in the elderly, based on the perspective of cognitive function in patients with multiple chronic diseases.</p><p><strong>Methods: </strong>Our study was based on the data from the 2023 China Psychological Care for the Elderly Action Survey, and the SPSS 26.0 (IBM Corp., Armonk, NY, United States) software package was used for mediation model analysis. The approach encompassed descriptive analysis of variables, Spearman's correlation analyses to explore associations between variables, and a moderated mediation analysis.</p><p><strong>Results: </strong>The study found that the number of chronic diseases (<i>r</i> = 0.183, <i>p</i> < 0.001) was positively correlated with cognitive function. Anxiety and depression partially mediated the relationship between the number of chronic diseases and cognitive function (<i>β</i> = 0.227, 0.235, both <i>p</i> < 0.001). Age moderated the association between the number of chronic diseases and depression (<i>β</i> = 0.010, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This study provides a comprehensive mediation model that establishes a new association between the number of chronic diseases and cognitive function in older adults. It suggests that we should pay attention to the negative impact of multiple chronic diseases on cognitive function of the elderly and improve their psychological coping ability, so as to ensure the stable development of healthy aging.</p>","PeriodicalId":12525,"journal":{"name":"Frontiers in Psychology","volume":"16 ","pages":"1491382"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913165/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Psychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.3389/fpsyg.2025.1491382","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PSYCHOLOGY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: Despite the wealth of data on the role of chronic disease comorbidity in shaping cognitive dysfunction in older adults, a comprehensive view of this dynamic interplay remains a frontier. This study will reveal the intricate interactions between the number of chronic diseases and cognitive function in the elderly, based on the perspective of cognitive function in patients with multiple chronic diseases.
Methods: Our study was based on the data from the 2023 China Psychological Care for the Elderly Action Survey, and the SPSS 26.0 (IBM Corp., Armonk, NY, United States) software package was used for mediation model analysis. The approach encompassed descriptive analysis of variables, Spearman's correlation analyses to explore associations between variables, and a moderated mediation analysis.
Results: The study found that the number of chronic diseases (r = 0.183, p < 0.001) was positively correlated with cognitive function. Anxiety and depression partially mediated the relationship between the number of chronic diseases and cognitive function (β = 0.227, 0.235, both p < 0.001). Age moderated the association between the number of chronic diseases and depression (β = 0.010, p < 0.001).
Conclusion: This study provides a comprehensive mediation model that establishes a new association between the number of chronic diseases and cognitive function in older adults. It suggests that we should pay attention to the negative impact of multiple chronic diseases on cognitive function of the elderly and improve their psychological coping ability, so as to ensure the stable development of healthy aging.
期刊介绍：
Frontiers in Psychology is the largest journal in its field, publishing rigorously peer-reviewed research across the psychological sciences, from clinical research to cognitive science, from perception to consciousness, from imaging studies to human factors, and from animal cognition to social psychology. Field Chief Editor Axel Cleeremans at the Free University of Brussels is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal publishes the best research across the entire field of psychology. Today, psychological science is becoming increasingly important at all levels of society, from the treatment of clinical disorders to our basic understanding of how the mind works. It is highly interdisciplinary, borrowing questions from philosophy, methods from neuroscience and insights from clinical practice - all in the goal of furthering our grasp of human nature and society, as well as our ability to develop new intervention methods.
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