Clinical Profile of Metabolic Derangements in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Q3 Medicine
Saroj Babu Aryal, Akriti Panthi, Nadira Aryal, Bijay Risal
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引用次数: 0

Abstract

Background: Chronic obstructive pulmonary disease is defined as a preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation attributable to airway accompanied by alveolar abnormalities elicited by significant exposure to noxious particles or gases. Stress hormone is involved in proclivity towards causation of hyperglycemia and hyponatremia in COPD.

Methods: This study is an analytical cross sectional single center study that was carried out in Tribhuvan University Teaching Hospital. Specimens were processed as per the guidelines of Standard Operating Procedure (SOP) of Biochemistry laboratory of Tribhuvan University Teaching Hospital.

Results: In this study of 138 patients with acute exacerbation of COPD, the mean age was (71.88±9.771) years with higher prevalence in the age group between 70-80 years of age. Females (65.2%) outnumbered males and 71.7% came from outside the Kathmandu valley. Hyponatremia was observed in sodium levels with 51.4% below normal with majority of patient's possessing mixed acid-base disorders (58.7%). Most of thepatients 76.5% received general care with a mean hospital stay of 8.7 days. Statistical analysis revealed significant associations between care type, geographical distribution (p=0.026) and duration of stay with care type (p=0.0001). No significant associations were found regarding gender, glucose, sodium, potassium levels and age with duration of stay.

Conclusions: Factors such as age, gender, and glycemic status did not significantly affect the type of care or duration of hospital stay, geographical location emerged as a significant determinant, with patients from outside the Kathmandu valley more likely to receive general care. Despite the prevalence of electrolyte imbalances and acid-base disorders, these biochemical factors showed no substantial impact on clinical outcomes, suggesting that other factors may play a more significant role in duration of stay.

慢性阻塞性肺疾病急性加重期患者代谢紊乱的临床特征
背景:慢性阻塞性肺疾病被定义为一种可预防和可治疗的疾病,其特征是由气道引起的持续呼吸道症状和气流限制,并伴有因大量暴露于有毒颗粒或气体而引起的肺泡异常。应激激素参与慢性阻塞性肺病患者高血糖和低钠血症的发生。方法:本研究采用分析性横断面单中心研究,在特里布万大学附属医院进行。标本按照特里布万大学教学医院生物化学实验室标准操作程序(SOP)进行处理。结果:138例慢性阻塞性肺病急性加重患者,平均年龄为(71.88±9.771)岁,70 ~ 80岁年龄组患病率较高。女性(65.2%)超过男性,71.7%来自加德满都谷地以外。低钠血症发生率为51.4%,多数患者伴有混合性酸碱失调(58.7%)。大多数患者(76.5%)接受一般护理,平均住院时间为8.7天。统计分析显示护理类型、地理分布(p=0.026)与护理类型住院时间(p=0.0001)有显著相关。性别、血糖、钠、钾水平和年龄与住院时间没有明显关联。结论:年龄、性别和血糖状态等因素对护理类型或住院时间没有显著影响,地理位置成为一个重要的决定因素,加德满都谷地以外的患者更有可能接受一般护理。尽管电解质失衡和酸碱紊乱普遍存在,但这些生化因素对临床结果没有实质性影响,这表明其他因素可能在住院时间中发挥更重要的作用。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
81
审稿时长
15 weeks
期刊介绍: The journal publishes articles related to researches done in the field of biomedical sciences related to all the discipline of the medical sciences, medical education, public health, health care management, including ethical and social issues pertaining to health. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews and meta-analysis. Editorial, Guest Editorial, Viewpoint and letter to the editor are solicited by the editorial board. Frequently Asked Questions (FAQ) regarding manuscript submission and processing at JNHRC.
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